PMID- 27501330
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20180628
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 27
IP  - 8
DP  - 2016 Dec
TI  - Early polysensitization is associated with allergic multimorbidity in PARIS birth 
      cohort infants.
PG  - 831-837
LID - 10.1111/pai.12622 [doi]
AB  - BACKGROUND: Profiles of allergic sensitization are poorly documented in infancy. 
      Relations between early sensitization and allergic morbidity need to be 
      clarified. METHODS: This study dealt with children involved in the Pollution and 
      Asthma Risk: an Infant Study (PARIS), a population-based prospective birth 
      cohort. Allergic sensitization to twelve food and four inhalant allergens was 
      assessed at 18 months and defined by a specific immunoglobulin E (IgE) level 
      >/=0.35 kU(A) /l. Health data were collected by standardized questionnaires at 2 
      and 6 years. Early allergic profiles were identified by an unsupervised cluster 
      analysis based on health data at 2 years and IgE measurements. Profiles were 
      compared with regard to allergic morbidity and multimorbidity at 6 years. 
      RESULTS: Sensitization to any allergen concerned 13.6% of infants. By cluster 
      analysis, 1525 infants were grouped into three profiles: 89.2% not or rarely 
      sensitized (only 3.7% of sensitized), 9.2% mainly sensitized to one or few 
      allergens (45.2% of monosensitized and 45.9% of paucisensitized) and 1.6% all 
      polysensitized. The prevalence of doctor-diagnosed asthma, rhinitis, eczema, food 
      allergy and multimorbidity at 2 years increased from profile one to profile three 
      (p-trend <0.001). At 6 years, symptoms of current asthma, rhinitis, eczema and 
      multimorbidity were significantly more frequent in the last two profiles. 
      CONCLUSIONS: This study highlights, as early as 18 months of age, three profiles 
      of increasing severity with regard to allergic sensitization and diseases. These 
      profiles also differ in terms of allergic morbidity at 6 years. Early 
      sensitization can predict allergic multimorbidity in childhood, and in the case 
      of early polysensitization, multimorbidity is more frequent as soon as infancy.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Gabet, Stephan
AU  - Gabet S
AD  - EA 4064 Epidemiologie environnementale, Universite Paris Descartes, Sorbonne 
      Paris Cite, Paris, France.
AD  - Cellule Cohorte, Direction de l'Action Sociale, de l'Enfance et de la Sante, 
      Mairie de Paris, Paris, France.
FAU - Just, Jocelyne
AU  - Just J
AD  - Centre de l'Asthme et des Allergies, Groupe Hospitalier d'Enfants Trousseau-La 
      Roche Guyon, Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Couderc, Remy
AU  - Couderc R
AD  - Service de Biochimie et Biologie Moleculaire, Hopital d'Enfants Armand Trousseau, 
      Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Bousquet, Jean
AU  - Bousquet J
AD  - VIMA: Vieillissement et maladies chroniques. Approches epidemiologiques et de 
      sante publique, U1168, INSERM, Paris, France.
AD  - UMR-S 1168, Universite de Versailles Saint-Quentin, Versailles, France.
FAU - Seta, Nathalie
AU  - Seta N
AD  - EA 4064 Epidemiologie environnementale, Universite Paris Descartes, Sorbonne 
      Paris Cite, Paris, France.
AD  - Departement de Biochimie, Hopital Bichat, Assistance Publique-Hopitaux de Paris, 
      Paris, France.
FAU - Momas, Isabelle
AU  - Momas I
AD  - EA 4064 Epidemiologie environnementale, Universite Paris Descartes, Sorbonne 
      Paris Cite, Paris, France.
AD  - Cellule Cohorte, Direction de l'Action Sociale, de l'Enfance et de la Sante, 
      Mairie de Paris, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160921
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Pediatr Allergy Immunol. 2020 Aug;31(6):722. PMID: 32757336
MH  - Allergens/*immunology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cross Reactions
MH  - Female
MH  - Follow-Up Studies
MH  - Food
MH  - Humans
MH  - Hypersensitivity/diagnosis/*epidemiology
MH  - *Immunization
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Population Groups
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
OTO - NOTNLM
OT  - allergic morbidity
OT  - birth cohort
OT  - cluster analysis
OT  - early allergic profiles
OT  - immunoglobulin E
OT  - polysensitization
EDAT- 2016/08/09 06:00
MHDA- 2017/12/30 06:00
CRDT- 2016/08/09 06:00
PHST- 2016/08/03 00:00 [accepted]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
PHST- 2016/08/09 06:00 [entrez]
AID - 10.1111/pai.12622 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2016 Dec;27(8):831-837. doi: 10.1111/pai.12622. Epub 
      2016 Sep 21.