PMID- 27502250
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20221207
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 461
DP  - 2016 Oct 1
TI  - Glycemic variability evaluated by continuous glucose monitoring system is 
      associated with the 10-y cardiovascular risk of diabetic patients with 
      well-controlled HbA1c.
PG  - 146-50
LID - S0009-8981(16)30342-4 [pii]
LID - 10.1016/j.cca.2016.08.004 [doi]
AB  - BACKGROUND: The present study aimed to identify the relationship between glycemic 
      variability (GV) and the 10-y risk of cardiovascular disease (CVD) in type 2 
      diabetes mellitus (T2DM) patients with good glycemic control. METHODS: 
      Two-hundred forty consecutive T2DM patients (HbA1c</=7.0%) without CVD were 
      included to calculate the 10-y CVD risk by Framingham risk score (FRS), and 
      divided into 3 groups: low-risk group (FRS</=10%), intermediate-risk group (>10%, 
      </=20%) and high-risk group (>20%). Inter-group differences of GV were determined 
      by comparing the SD of blood glucose (SDBG), mean amplitudes of glycemic 
      excursion (MAGE), and mean of daily differences (MODD) gathered from 72-h 
      continuous glucose monitoring system. RESULTS: The levels of SDBG and MAGE 
      significantly increased along with the raises of 10-y CVD risk of T2DM patients 
      (p<0.01). FRS was positively correlated with age, systolic blood pressure, SDBG 
      and MAGE (r=0.717, 0.525, 0.509 and 0.485 respectively, p<0.01), while negatively 
      correlated with the level of HDL-C (r=-0.348, p<0.01). Furthermore, multivariate 
      logistic regression analysis confirmed that increased MAGE [OR: 
      1.623(1.198-2.316), p<0.001] and patients with high urine albumin excretion rates 
      [OR: 1.743(1.247-2.793), p<0.001] were independent predictors for high 10-y CVD 
      risk. CONCLUSION: GV predicts independently the 10-y CVD risk of T2DM patients 
      with well-controlled HbA1c.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Tang, Xixiang
AU  - Tang X
AD  - Advanced Medical Center, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Li, Suhua
AU  - Li S
AD  - Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Wang, Yina
AU  - Wang Y
AD  - Advanced Medical Center, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Wang, Manman
AU  - Wang M
AD  - Division of Endocrinology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Yin, Qiongli
AU  - Yin Q
AD  - Advanced Medical Center, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Mu, Panwei
AU  - Mu P
AD  - Division of Endocrinology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Lin, Shuo
AU  - Lin S
AD  - Division of Endocrinology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Qian, Xiaoxian
AU  - Qian X
AD  - Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Ye, Xiaoming
AU  - Ye X
AD  - Advanced Medical Center, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China.
FAU - Chen, Yanming
AU  - Chen Y
AD  - Division of Endocrinology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Tian-he Road, Guangzhou 510630, China. Electronic address: txx_8711@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160805
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - *Blood Glucose Self-Monitoring
MH  - Cardiovascular Diseases/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Glycemic Index
MH  - *Glycemic Load
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Framingham risk score
OT  - Glycemic variability
OT  - Type 2 diabetes mellitus
EDAT- 2016/08/10 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/08/10 06:00
PHST- 2015/10/25 00:00 [received]
PHST- 2016/07/16 00:00 [revised]
PHST- 2016/08/04 00:00 [accepted]
PHST- 2016/08/10 06:00 [entrez]
PHST- 2016/08/10 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
AID - S0009-8981(16)30342-4 [pii]
AID - 10.1016/j.cca.2016.08.004 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2016 Oct 1;461:146-50. doi: 10.1016/j.cca.2016.08.004. Epub 2016 
      Aug 5.