PMID- 27502782
OWN - NLM
STAT- MEDLINE
DCOM- 20180207
LR  - 20190131
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Print)
IS  - 0143-005X (Linking)
VI  - 71
IP  - 1
DP  - 2017 Jan
TI  - Periodontitis is an independent risk indicator for atherosclerotic cardiovascular 
      diseases among 60 174 participants in a large dental school in the Netherlands.
PG  - 37-42
LID - 10.1136/jech-2015-206745 [doi]
AB  - BACKGROUND: The association between periodontitis and atherosclerotic 
      cardiovascular diseases (ACVD) has been established in some modestly sized 
      studies (<10 000). Rarely, however, periodontitis has been studied directly; 
      often tooth loss or self-reported periodontitis has been used as a proxy measure 
      for periodontitis. Our aim is to investigate the adjusted association between 
      periodontitis and ACVD among all individuals registered in a large dental school 
      in the Netherlands (Academic Centre for Dentistry Amsterdam (ACTA)). METHODS: 
      Anonymised data were extracted from the electronic health records for all 
      registered patients aged >35 years (period 1998-2013). A participant was recorded 
      as having periodontitis based on diagnostic and treatment codes. Any affirmative 
      answer for cerebrovascular accidents, angina pectoris and/or myocardial 
      infarction labelled a participant as having ACVD. Other risk factors for ACVD, 
      notably age, sex, smoking, diabetes, hypertension, hypercholesterolaemia and 
      social economic status, were also extracted. Logistic regression analyses were 
      used to evaluate the adjusted associations between periodontitis and ACVD. 
      RESULTS: 60 174 individuals were identified; 4.7% of the periodontitis 
      participants (455/9730) and 1.9% of the non-periodontitis participants 
      (962/50 444) reported ACVD; periodontitis showed a significant association with 
      ACVD (OR 2.52; 95% CI 2.3 to 2.8). After adjustment for the confounders, 
      periodontitis remained independently associated with ACVD (OR 1.59; 95% CI 1.39 
      to 1.81). With subsequent stratification for age and sex, periodontitis remained 
      independently associated with ACVD. CONCLUSIONS: This cross-sectional analysis of 
      a large cohort in the Netherlands of 60 174 participants shows the independent 
      association of periodontitis with ACVD.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Beukers, Nicky G F M
AU  - Beukers NG
AD  - Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
FAU - van der Heijden, Geert J M G
AU  - van der Heijden GJ
AD  - Department of Public Oral Health, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
FAU - van Wijk, Arjen J
AU  - van Wijk AJ
AD  - Department of Public Oral Health, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
FAU - Loos, Bruno G
AU  - Loos BG
AD  - Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/epidemiology/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Periodontitis/*complications/epidemiology
MH  - Risk Factors
MH  - Schools, Dental
PMC - PMC5256268
OTO - NOTNLM
OT  - ARTHEROSCLEROSIS
OT  - BLOOD PRESSURE
OT  - Cardiovascular disease
OT  - Clinical epidemiology
OT  - ORAL HEALTH
COIS- Conflicts of Interest: None declared.
EDAT- 2016/08/10 06:00
MHDA- 2018/02/08 06:00
PMCR- 2017/01/23
CRDT- 2016/08/10 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2016/03/22 00:00 [revised]
PHST- 2016/06/07 00:00 [accepted]
PHST- 2016/08/10 06:00 [pubmed]
PHST- 2018/02/08 06:00 [medline]
PHST- 2016/08/10 06:00 [entrez]
PHST- 2017/01/23 00:00 [pmc-release]
AID - jech-2015-206745 [pii]
AID - 10.1136/jech-2015-206745 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2017 Jan;71(1):37-42. doi: 
      10.1136/jech-2015-206745. Epub 2016 Aug 8.