PMID- 27503056 OWN - NLM STAT- MEDLINE DCOM- 20170103 LR - 20181202 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 218 DP - 2016 Nov TI - Serum POP concentrations are highly predictive of inner blubber concentrations at two extremes of body condition in northern elephant seals. PG - 651-663 LID - S0269-7491(16)30627-3 [pii] LID - 10.1016/j.envpol.2016.07.052 [doi] AB - Long-lived, upper trophic level marine mammals are vulnerable to bioaccumulation of persistent organic pollutants (POPs). Internal tissues may accumulate and mobilize POP compounds at different rates related to the body condition of the animal and the chemical characteristics of individual POP compounds; however, collection of samples from multiple tissues is a major challenge to ecotoxicology studies of free-ranging marine mammals and the ability to predict POP concentrations in one tissue from another tissue remains rare. Northern elephant seals (Mirounga angustirostris) forage on mesopelagic fish and squid for months at a time in the northeastern Pacific Ocean, interspersed with two periods of fasting on land, which results in dramatic seasonal fluctuations in body condition. Using northern elephant seals, we examined commonly studied tissues in mammalian toxicology to describe relationships and determine predictive equations among tissues for a suite of POP compounds, including SigmaDDTs, SigmaPCBs, Sigmachlordanes, and SigmaPBDEs. We collected paired blubber (inner and outer) and blood serum samples from adult female and male seals in 2012 and 2013 at Ano Nuevo State Reserve (California, USA). For females (N = 24), we sampled the same seals before (late in molting fast) and after (early in breeding fast) their approximately seven month foraging trip. For males, we sampled different seals before (N = 14) and after (N = 15) their approximately four month foraging trip. We observed strong relationships among tissues for many, but not all compounds. Serum POP concentrations were strong predictors of inner blubber POP concentrations for both females and males, while serum was a more consistent predictor of outer blubber for males than females. The ability to estimate POP blubber concentrations from serum, or vice versa, has the potential to enhance toxicological assessment and physiological modeling. Furthermore, predictive equations may illuminate commonalities or distinctions in bioaccumulation across marine mammal species. CI - Copyright (c) 2016 Elsevier Ltd. All rights reserved. FAU - Peterson, Michael G AU - Peterson MG AD - Department of Environmental Science, Policy and Management, University of California, Berkeley, Berkeley, CA 94720-3114, USA. Electronic address: petersmg@berkeley.edu. FAU - Peterson, Sarah H AU - Peterson SH AD - Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 100 Shaffer Road, Santa Cruz, CA 95060, USA. FAU - Debier, Cathy AU - Debier C AD - Institut des Sciences de la Vie, Universite catholique de Louvain, Croix du Sud 2/L7.05.08, 1348, Louvain-la-Neuve, Belgium. FAU - Covaci, Adrian AU - Covaci A AD - Toxicological Center, Universiteit Antwerpen, Universiteitsplein 1, 2610, Wilrijk, Belgium. FAU - Dirtu, Alin C AU - Dirtu AC AD - Toxicological Center, Universiteit Antwerpen, Universiteitsplein 1, 2610, Wilrijk, Belgium; Department of Chemistry, "Al. I. Cuza" University of Iasi, Carol I Bvd, No. 11, 700506, Iasi, Romania. FAU - Malarvannan, Govindan AU - Malarvannan G AD - Toxicological Center, Universiteit Antwerpen, Universiteitsplein 1, 2610, Wilrijk, Belgium. FAU - Crocker, Daniel E AU - Crocker DE AD - Department of Biology, Sonoma State University, 1801 East Cotati Ave, Rohnert Park, CA 94928, USA. FAU - Costa, Daniel P AU - Costa DP AD - Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 100 Shaffer Road, Santa Cruz, CA 95060, USA. LA - eng PT - Journal Article DEP - 20160805 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Water Pollutants, Chemical) SB - IM MH - Adipose Tissue/*chemistry/*metabolism MH - Animals MH - Body Composition/*physiology MH - California MH - Female MH - Male MH - Pacific Ocean MH - *Seals, Earless MH - Water Pollutants, Chemical/*chemistry/metabolism OTO - NOTNLM OT - Fasting OT - Marine mammal OT - Partitioning coefficients OT - Pinniped OT - Predictive-equations OT - Tissue-correlation EDAT- 2016/08/10 06:00 MHDA- 2017/01/04 06:00 CRDT- 2016/08/10 06:00 PHST- 2016/03/22 00:00 [received] PHST- 2016/07/22 00:00 [revised] PHST- 2016/07/22 00:00 [accepted] PHST- 2016/08/10 06:00 [pubmed] PHST- 2017/01/04 06:00 [medline] PHST- 2016/08/10 06:00 [entrez] AID - S0269-7491(16)30627-3 [pii] AID - 10.1016/j.envpol.2016.07.052 [doi] PST - ppublish SO - Environ Pollut. 2016 Nov;218:651-663. doi: 10.1016/j.envpol.2016.07.052. Epub 2016 Aug 5.