PMID- 27503551 OWN - NLM STAT- MEDLINE DCOM- 20170424 LR - 20181113 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 32 IP - 11 DP - 2016 Nov TI - Early gadolinium enhancement in hypertrophic cardiomyopathy: a potential premature marker of myocardial damage. PG - 1635-1643 AB - Early gadolinium enhancement (EGE), one CMR diagnostic criteria in acute myocarditis, has been related with hyperemia and capillary leakage. The value of EGE in hypertrophic cardiomyopathy (HCM) remains unknown. Our aim was to determine the prevalence of EGE in patients with HCM, and its relation with late gadolinium enhancement (LGE). The association of EGE with morphological and clinical parameters was also evaluated. Sixty consecutive patients with HCM and CMR from our center were included. All the clinical and complementary test information was collected prospectively in our HCM clinic. Left ventricular (LV) measurements were calculated from cine sequences. EGE and LGE were quantified with a dedicated software. Clinical events were collected from medical records. A slow wash-out pattern on EGE was detected in up to 68 % of the patients, being an isolated finding without LGE in 10 (16 %). This cohort showed a greater maximal LV wall thickness (20.1 +/- 4 vs. 18.1 +/- 3.5 mm, p = 0.010) and asymmetry ratio (1.86 +/- 0.42 vs. 1.62 +/- 0.46; p = 0.039). The percentage of EGE/slice and the difference with the percentage LGE/slice demonstrated a significant positive correlation with the maximal LV wall thickness (Rho 0.450 and 0.386 respectively). EGE also correlated with number of segments with LVH (LV hypertrophy) and the asymmetry ratio. Neither EGE nor LGE were associated with classical risk factors, the risk score for sudden cardiac death, or with major clinical events. EGE was a frequent finding in HCM, even in absence of LGE. This phenomenon showed a positive correlation with morphological markers of disease burden. FAU - Pozo, Eduardo AU - Pozo E AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. eduardopozoosinalde@yahoo.es. FAU - Viliani, Dafne AU - Viliani D AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. FAU - Aguirre, Norma AU - Aguirre N AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. FAU - Agudo-Quilez, Pilar AU - Agudo-Quilez P AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. FAU - Olivera, Maria Jose AU - Olivera MJ AD - Radiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Caballero, Paloma AU - Caballero P AD - Radiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Jimenez-Borreguero, Luis Jesus AU - Jimenez-Borreguero LJ AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. AD - Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. FAU - Alfonso, Fernando AU - Alfonso F AD - Cardiology Department, Hospital Universitario de La Princesa, IIS-IP, Universidad Autonoma de Madrid, Calle de Diego Leon, 62, 28006, Madrid, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20160809 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 6HG8UB2MUY (Meglumine) RN - L0ND3981AG (gadoterate meglumine) SB - IM MH - Aged MH - Cardiomyopathy, Hypertrophic/complications/*diagnostic imaging/mortality MH - Contrast Media/*administration & dosage MH - Death, Sudden, Cardiac/etiology MH - Early Diagnosis MH - Female MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Meglumine/*administration & dosage MH - Middle Aged MH - Organometallic Compounds/*administration & dosage MH - Predictive Value of Tests MH - Prognosis MH - Risk Factors MH - Spain OTO - NOTNLM OT - Cardiac magnetic resonance OT - Early gadolinium enhancement OT - Hypertrophic cardiomyopathy OT - Late gadolinium enhancement EDAT- 2016/08/10 06:00 MHDA- 2017/04/25 06:00 CRDT- 2016/08/10 06:00 PHST- 2016/05/25 00:00 [received] PHST- 2016/08/01 00:00 [accepted] PHST- 2016/08/10 06:00 [pubmed] PHST- 2017/04/25 06:00 [medline] PHST- 2016/08/10 06:00 [entrez] AID - 10.1007/s10554-016-0954-5 [pii] AID - 10.1007/s10554-016-0954-5 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2016 Nov;32(11):1635-1643. doi: 10.1007/s10554-016-0954-5. Epub 2016 Aug 9.