PMID- 27504458
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20220330
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Association between Serum Albumin Concentration and Ketosis Risk in Hospitalized 
      Individuals with Type 2 Diabetes Mellitus.
PG  - 1269706
LID - 10.1155/2016/1269706 [doi]
LID - 1269706
AB  - Objective. This study examined the association between serum albumin 
      concentration and ketosis risk in hospitalized individuals with type 2 diabetes 
      mellitus (T2DM). Methods. A retrospective cross-sectional study was conducted at 
      a medical center in Taiwan. Inclusion criteria were endocrinology ward inpatients 
      exceeding 21 years of age, with preexisting diagnosis of T2DM, and blood glucose 
      above 13.9 millimoles per liter (mmol/L) at admission. Individuals without 
      measurement of serum albumin, urine ketone, or hemoglobin A1C, or harboring 
      active infection, myocardial infarction, cerebrovascular event, cirrhosis, 
      malignancy, or overt proteinuria were excluded. Using serum albumin concentration 
      below 3.0 grams per deciliter to define hypoalbuminemia, 151 hypoalbuminemic 
      cases and 104 normoalbuminemic controls were enrolled. The presence of ketones in 
      urine established ketosis. Results. The prevalence of ketonuria was 48% in 
      hypoalbuminemic subjects compared to 30% in normoalbuminemic controls (odds ratio 
      (OR): 2.15; 95% confidence interval (CI): 1.26-3.57; P = 0.004). Moreover, among 
      the 156 subjects with serum beta-hydroxybutyrate measurement in addition to urine 
      ketone, 33% of the hypoalbuminemic individuals had ketonemia exceeding 3 mmol/L 
      compared to 19% of those with normoalbuminemia (OR: 2.12, 95% CI: 0.99-4.48, P = 
      0.051). Conclusions. Serum albumin concentration is inversely associated with 
      ketosis risk in hospitalized individuals with T2DM.
FAU - Cheng, Po-Chung
AU  - Cheng PC
AUID- ORCID: 0000-0001-9655-2034
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, 135 Nanxiao Street, Changhua City, Changhua County 
      500, Taiwan.
FAU - Hsu, Shang-Ren
AU  - Hsu SR
AUID- ORCID: 0000-0001-9849-9628
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, 135 Nanxiao Street, Changhua City, Changhua County 
      500, Taiwan.
FAU - Cheng, Yun-Chung
AU  - Cheng YC
AUID- ORCID: 0000-0001-6665-876X
AD  - Department of Radiology, Taichung Veterans General Hospital, 1650 Taiwan 
      Boulevard Sector 4, Taichung 40705, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20160718
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Aged
MH  - Blood Glucose
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Ketosis/blood/epidemiology/*etiology
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serum Albumin/*analysis
PMC - PMC4967705
EDAT- 2016/08/10 06:00
MHDA- 2017/06/01 06:00
PMCR- 2016/07/18
CRDT- 2016/08/10 06:00
PHST- 2016/01/24 00:00 [received]
PHST- 2016/06/26 00:00 [accepted]
PHST- 2016/08/10 06:00 [entrez]
PHST- 2016/08/10 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/07/18 00:00 [pmc-release]
AID - 10.1155/2016/1269706 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:1269706. doi: 10.1155/2016/1269706. Epub 2016 Jul 18.