PMID- 27504897
OWN - NLM
STAT- MEDLINE
DCOM- 20170329
LR  - 20170330
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 94
IP  - 2
DP  - 2016
TI  - Association of Intestinal Microbiota with Metabolic Markers and Dietary Habits in 
      Patients with Type 2 Diabetes.
PG  - 66-72
AB  - BACKGROUND/AIMS: Evidence suggests that intestinal microbiota, along with factors 
      such as diet and host genetics, contributes to obesity, metabolic dysfunction and 
      diabetes. Therefore, we examined the relationship between gut microbiota, blood 
      metabolic markers, dietary habits and fecal short-chain fatty acids (SCFAs) in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: Dietary habits, blood and 
      fecal samples from 59 T2DM patients were recruited, and the association of 
      intestinal microbiota with metabolic markers and dietary habits was analyzed. 
      RESULTS: Total energy intake was 1,692 +/- 380 kcal/day. Carbohydrate, fat and 
      protein intakes were 57.5 +/- 5.2, 23.2 +/- 5.3 and 13.2 +/- 2.2%, respectively. 
      Dietary habits - high carbohydrate, fat, and protein intake - were associated 
      with increased counts of Clostridium clusters IV and XI and decreased counts of 
      Bifidobacterium spp., order Lactobacillales and Clostridium cluster IV. Protein 
      intake was negatively correlated with fecal acetate and total SCFAs. Total SCFAs, 
      propionate and acetate were negatively correlated with blood insulin levels and 
      the homeostasis model of insulin resistance. CONCLUSION: Diets low in protein and 
      carbohydrates favor a healthy gut microbiome and improve glucose tolerance in 
      T2DM patients, although further elucidation of the role of the gut microbiome 
      could lead to better therapies and prophylaxes.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Yamaguchi, Yoshiharu
AU  - Yamaguchi Y
AD  - Department of Gastroenterology, Aichi Medical University School of Medicine, 
      Nagakute, Japan.
FAU - Adachi, Kazunori
AU  - Adachi K
FAU - Sugiyama, Tomoya
AU  - Sugiyama T
FAU - Shimozato, Akihiro
AU  - Shimozato A
FAU - Ebi, Masahide
AU  - Ebi M
FAU - Ogasawara, Naotaka
AU  - Ogasawara N
FAU - Funaki, Yasushi
AU  - Funaki Y
FAU - Goto, Chiho
AU  - Goto C
FAU - Sasaki, Makoto
AU  - Sasaki M
FAU - Kasugai, Kunio
AU  - Kasugai K
LA  - eng
PT  - Journal Article
DEP - 20160810
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Energy Intake
MH  - Fatty Acids, Volatile/analysis
MH  - Feces/microbiology
MH  - *Feeding Behavior
MH  - Female
MH  - *Gastrointestinal Microbiome
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Japan
MH  - Male
MH  - Middle Aged
EDAT- 2016/10/19 06:00
MHDA- 2017/03/31 06:00
CRDT- 2016/08/10 06:00
PHST- 2016/04/18 00:00 [received]
PHST- 2016/06/17 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2016/08/10 06:00 [entrez]
AID - 000447690 [pii]
AID - 10.1159/000447690 [doi]
PST - ppublish
SO  - Digestion. 2016;94(2):66-72. doi: 10.1159/000447690. Epub 2016 Aug 10.