PMID- 27505300
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20171009
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 162
DP  - 2016 Sep
TI  - Radio-protective effect of some new curcumin analogues.
PG  - 694-702
LID - S1011-1344(16)30238-X [pii]
LID - 10.1016/j.jphotobiol.2016.08.002 [doi]
AB  - In the present study, novel symmetrical curcumin analogues (2-7) have been 
      synthesized by substituting the phenolic OH of curcumin with different linkers 
      providing additional keto-enol tautomerism, very essential for radioprotective 
      activity. The structures of the synthesized compounds (2-7) were elucidated by 
      elemental analysis, IR, (1)H-NMR, (13)C-NMR and mass spectral data and were found 
      consistent with the assigned structures. The curative effect of these new 
      compounds, against the oxidative stress due to exposure of rats to the whole body 
      gamma-irradiation (7Gy) was investigated. Gamma-irradiated rats exhibited elevations 
      of ALT, AST activities, urea, creatinine, triglycerides, total cholesterol, 
      malondialdehyde (MDA), nitric oxide (NO), Interleukin-6 (IL-6), Tumor Necrosis 
      Factor-alpha (TNF-alpha) and Nuclear Factor-kappa B (NF-kappaB) levels. Contrariwise, the 
      total protein, albumin, total calcium level, SOD, CAT, GSH-Px, GST activities and 
      GSH content were decreased. Treatment of gamma-irradiated rats with the new 
      curcumin analogues (2-7) showed significant amelioration in the in-vivo 
      antioxidant status, liver and kidney functions, as well as the anti-inflammatory 
      markers (IL-6, TNF-alpha and NF-kappaB). Inhibition of NF-kappaB could be responsible for the 
      improvement of the antioxidant and anti-inflammatory status in gamma-irradiated 
      animals, by down-regulation of IL-1beta and TNF-alpha level. In conclusion, the new 
      curcumin analogues (2-7) exhibited post-protective effect on gamma-irradiation, 
      by NF-kappaB inhibition.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - El-Gazzar, Marwa G
AU  - El-Gazzar MG
AD  - Drug Radiation Research Department, National Center for Radiation Research & 
      Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor 
      St., P.O. Box: 29, Nasr City, Cairo, Egypt. Electronic address: 
      marwa.galal@eaea.org.eg.
FAU - Zaher, Nashwa H
AU  - Zaher NH
AD  - Drug Radiation Research Department, National Center for Radiation Research & 
      Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor 
      St., P.O. Box: 29, Nasr City, Cairo, Egypt.
FAU - El-Hossary, Ebaa M
AU  - El-Hossary EM
AD  - Drug Radiation Research Department, National Center for Radiation Research & 
      Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor 
      St., P.O. Box: 29, Nasr City, Cairo, Egypt.
FAU - Ismail, Amel F M
AU  - Ismail AFM
AD  - Drug Radiation Research Department, National Center for Radiation Research & 
      Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), 3 Ahmed El-Zomor 
      St., P.O. Box: 29, Nasr City, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20160802
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Radiation-Protective Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Biomarkers/blood
MH  - Catalase/metabolism
MH  - Cholesterol/blood
MH  - Curcumin/analogs & derivatives/chemical synthesis/*pharmacology
MH  - Down-Regulation/*drug effects/radiation effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gamma Rays
MH  - Glutathione Peroxidase/metabolism
MH  - Interleukin-6/blood
MH  - Magnetic Resonance Spectroscopy
MH  - Malondialdehyde/blood
MH  - NF-kappa B/blood
MH  - Oxidative Stress/*drug effects/radiation effects
MH  - Radiation-Protective Agents/chemical synthesis/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Spectrophotometry, Infrared
MH  - Superoxide Dismutase/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Antioxidant
OT  - Curcumin
OT  - Gamma radiation
OT  - Nuclear Factor-kappa B
OT  - Radio-protective
EDAT- 2016/08/10 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/08/10 06:00
PHST- 2016/04/05 00:00 [received]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/10 06:00 [entrez]
PHST- 2016/08/10 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
AID - S1011-1344(16)30238-X [pii]
AID - 10.1016/j.jphotobiol.2016.08.002 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2016 Sep;162:694-702. doi: 
      10.1016/j.jphotobiol.2016.08.002. Epub 2016 Aug 2.