PMID- 27505625
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 120
DP  - 2016 Oct
TI  - Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with 
      diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis.
PG  - 40-6
LID - S0168-8227(16)30274-1 [pii]
LID - 10.1016/j.diabres.2016.07.016 [doi]
AB  - AIMS: The relationship between monocyte chemoattractant protein-1 (MCP-1) 2518 
      A/G polymorphism and diabetic retinopathy (DR) attracted intense interest 
      recently, but the reported results are controversial. A meta-analysis was 
      performed to assess the MCP-1 polymorphism associated with DR susceptibility in 
      type 2 diabetes mellitus. METHODS: Eligible studies were identified from PubMed, 
      Embase, Web of science, Chinese Biomedical database, and references of retrieved 
      articles. Pooled odds ratios (ORs) with their 95% confidence intervals (95%CI) 
      were calculated by fixed or random-effects models. RESULTS: Six studies involving 
      3415 patients without DR and 3468 with any DR were included in the final 
      meta-analysis. Each 5 studies evaluated the associations of MCP-1 polymorphism 
      and any DR and proliferative DR (PDR), respectively. Meta-analysis in fixed model 
      demonstrated a significant association between MCP-1 polymorphism and any DR 
      under the homozygous model (OR=1.36; 95%CI: 1.15-1.62, P<0.001), heterozygous 
      model (OR=1.20; 95%CI: 1.02-1.42, P=0.031), dominant model (OR=1.28; 95%CI: 
      1.10-1.50, P=0.002), recessive model (OR=1.17; 95%CI: 1.05-1.31, P=0.004), and 
      allelic model (OR=1.16; 95%CI: 1.07-1.25, P<0.001). Furthermore, a significant 
      association of MCP-1 polymorphism and DR progression from non-proliferative DR to 
      proliferative DR was identified under heterozygous model (OR=1.45; 95%CI: 
      1.04-2.02, P=0.030). Sensitivity analyses did not draw different findings. 
      CONCLUSIONS: Meta-analysis of existing data suggested that MCP-1 2518 A/G 
      polymorphism affected the risk of presence and progression of DR in type 2 
      diabetes mellitus.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Wei
AU  - Wang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - He, Miao
AU  - He M
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Huang, Wenyong
AU  - Huang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China. Electronic address: 
      andyhwyz@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160730
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/*complications/genetics
MH  - Diabetic Retinopathy/diagnosis/*etiology
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Gene polymorphisms
OT  - MCP-1
OT  - Meta-analysis
OT  - Monocyte chemoattractant protein
EDAT- 2016/08/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/08/10 06:00
PHST- 2016/05/20 00:00 [received]
PHST- 2016/07/01 00:00 [revised]
PHST- 2016/07/22 00:00 [accepted]
PHST- 2016/08/10 06:00 [entrez]
PHST- 2016/08/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0168-8227(16)30274-1 [pii]
AID - 10.1016/j.diabres.2016.07.016 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Oct;120:40-6. doi: 10.1016/j.diabres.2016.07.016. 
      Epub 2016 Jul 30.