PMID- 27506204
OWN - NLM
STAT- MEDLINE
DCOM- 20170405
LR  - 20211204
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 41
IP  - 11
DP  - 2016 Nov
TI  - Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS 
      Induced Model of Depression in Rat.
PG  - 3083-3094
AB  - Major depression is a life threatening neuropsychiatric disorder that produces 
      mental illness and major cause of morbidity. The present study was conducted to 
      evaluate the neuroprotective, neurotrophic and antioxidant potential of Bacopa 
      monnieri extract (BME) on chronic unpredictable stress (CUS) induced behavioral 
      depression in rats. Behavioral tests were carried out for investigation of 
      antidepressant like effects of BME, and potential mechanism was assessed by 
      determining neurotrophin level and hippocampal neurogenesis. Depressive-like 
      behavior was assessed by shuttle-box escape test, forced swim test and tail 
      suspension test. Effect of BME on hypothalamic-pituitary-adrenal (HPA) axis was 
      evaluated by measuring the plasma level of adrenocorticotropic hormone (ACTH) and 
      corticosterone. The expression of brain derived neurotrophic factor (BDNF), 
      neuronal marker doublecortin (DCX) in the hippocampus were measured and 
      hippocampal neurogenesis was investigated by 5-bromo-2-deoxyuridine/neuronal 
      nuclei (BrdU/NeuN). In addition, effects of BME on oxidative stress markers were 
      also measured in the hippocampus of CUS exposed rats. The results indicated that 
      BME significantly able to attenuate the depressive-like behaviors, normalized the 
      levels of ACTH, corticosterone, and up-regulate the expression of BDNF, DCX and 
      BrdU/NeuN in CUS induced rats compared to BME treated rats. It is also found that 
      BME significantly increased the activity of antioxidant enzymes on CUS induced 
      rats. These findings revealed that BME exerted neuroprotective effects possibly 
      by promoting hippocampal neurogenesis with elevation of BDNF level and 
      antioxidant defense against oxidative stress.
FAU - Kumar, Sourav
AU  - Kumar S
AD  - Neuroscience Research Unit, Raja Peary Mohan College, Uttarpara, Hooghly, West 
      Bengal, 712258, India.
FAU - Mondal, Amal Chandra
AU  - Mondal AC
AUID- ORCID: 0000-0003-0491-7804
AD  - Neuroscience Research Unit, Raja Peary Mohan College, Uttarpara, Hooghly, West 
      Bengal, 712258, India. acmondal@mail.jnu.ac.in.
AD  - School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India. 
      acmondal@mail.jnu.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20160810
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Bacopa/*metabolism
MH  - Behavior, Animal
MH  - Corticosterone/blood
MH  - Depression/*metabolism
MH  - Depressive Disorder, Major/*metabolism
MH  - Disease Models, Animal
MH  - Doublecortin Protein
MH  - Male
MH  - Neurogenesis/drug effects/physiology
MH  - Oxidative Stress/*drug effects
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*metabolism
OTO - NOTNLM
OT  - Antioxidant
OT  - BDNF
OT  - Bacopa monnieri
OT  - Chronic unpredictable stress
OT  - Depression
OT  - Hippocampal neurogenesis
EDAT- 2016/11/04 06:00
MHDA- 2017/04/06 06:00
CRDT- 2016/08/11 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/07/21 00:00 [revised]
PHST- 2016/11/04 06:00 [pubmed]
PHST- 2017/04/06 06:00 [medline]
PHST- 2016/08/11 06:00 [entrez]
AID - 10.1007/s11064-016-2029-3 [pii]
AID - 10.1007/s11064-016-2029-3 [doi]
PST - ppublish
SO  - Neurochem Res. 2016 Nov;41(11):3083-3094. doi: 10.1007/s11064-016-2029-3. Epub 
      2016 Aug 10.