PMID- 27506348
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20180118
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 934
DP  - 2016 Aug 31
TI  - Magnetic field assisted mu-solid phase extraction of anti-inflammatory and loop 
      diuretic drugs by modified polybutylene terephthalate nanofibers.
PG  - 88-97
LID - S0003-2670(16)30764-4 [pii]
LID - 10.1016/j.aca.2016.06.003 [doi]
AB  - A magnetic nanocomposite consisting of nanoparticles-polybutylene terephthalate 
      (MNPs-PBT) was electrospun and used as an extracting medium for an on-line 
      mu-solid phase extraction (mu-SPE)-high performance liquid chromatography (HPLC) 
      set-up with an ultraviolet (UV) detection system. Due to the magnetic property of 
      the prepared nanofibers, the whole extraction procedure was implemented under an 
      external magnetic field to enhance the extraction efficiencies. The developed 
      method along with the synthesized nanocomposite were found to be appropriate for 
      the determination of trace levels of selected drugs including furosemide, 
      naproxen, diclofenac and clobetasol propionate in the urine sample. The prepared 
      MNPs-PBT electrospun nanocomposite was characterized using the scanning electron 
      microscopy (SEM), energy dispersive spectroscopy (EDX) and Fourier transform 
      infrared (FT-IR) spectroscopy. The prepared magnetic fibers showed high porosity, 
      which was another driving force for the extraction efficiency enhancement. Major 
      parameters affecting the extraction efficiency of the selected drugs were 
      optimized. The limits of detections (LOD) of the studied drugs were in the range 
      of 0.4-1.6 mug L(-1) and the limits of quantification (LOQ) were 1-4 mug L(-1) 
      under the optimized conditions. Relative standard deviation (RSD%) for three 
      replicates at three concentration levels of 6, 100 and 400 mug L(-1) were 5.9-8.0% 
      while acceptable linear range with two orders of magnitude was obtained 
      (R(2) = 0.99). The method was validated by the determination of the selected 
      drugs in urine samples and the results indicated that this method has sufficient 
      potential for enrichment and determination of the desired drugs in the urine 
      sample. The relative recovery values were found to be in the range of 78-91%. 
      Implementing the developed on-line mu-SPE method under the external magnetic field 
      induction, led to higher extraction efficiencies for the selected drugs with 
      various diamagnetic properties.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Bagheri, Habib
AU  - Bagheri H
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran. Electronic address: 
      bagheri@sharif.edu.
FAU - Khanipour, Peyman
AU  - Khanipour P
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran.
FAU - Asgari, Sara
AU  - Asgari S
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160604
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Polyesters)
RN  - 0 (Sodium Potassium Chloride Symporter Inhibitors)
RN  - 26062-94-2 (poly(1,4-butylene terephthalate))
SB  - IM
MH  - Anti-Inflammatory Agents/chemistry/*isolation & purification
MH  - Magnetic Fields
MH  - Nanofibers/*chemistry
MH  - Particle Size
MH  - Polyesters/*chemistry
MH  - Sodium Potassium Chloride Symporter Inhibitors/chemistry/*isolation & 
      purification
MH  - *Solid Phase Extraction/instrumentation
MH  - Surface Properties
OTO - NOTNLM
OT  - Drugs analysis
OT  - Electrospinning
OT  - High performance liquid chromatography
OT  - Magnetic field assisted micro-solid phase extraction
OT  - Magnetic polybutylene terephthalate nanocomposite
OT  - On-line approach
EDAT- 2016/08/11 06:00
MHDA- 2018/01/19 06:00
CRDT- 2016/08/11 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2016/06/01 00:00 [revised]
PHST- 2016/06/02 00:00 [accepted]
PHST- 2016/08/11 06:00 [entrez]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - S0003-2670(16)30764-4 [pii]
AID - 10.1016/j.aca.2016.06.003 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2016 Aug 31;934:88-97. doi: 10.1016/j.aca.2016.06.003. Epub 2016 
      Jun 4.