PMID- 27506602
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20181202
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Aug 10
TI  - Peripheral brain-derived neurotrophic factor in autism spectrum disorder: a 
      systematic review and meta-analysis.
PG  - 31241
LID - 10.1038/srep31241 [doi]
LID - 31241
AB  - Brain-derived neurotrophic factor (BDNF) regulates neuronal survival and growth 
      and promotes synaptic plasticity. Recently, researchers have begun to explore the 
      relationship between peripheral BDNF levels and autism spectrum disorder (ASD), 
      but the findings are inconsistent. We undertook the first systematic review and 
      meta-analysis of studies examining peripheral BDNF levels in ASD compared with 
      healthy controls. The PubMed, Embase, and Cochrane Library databases were 
      searched for studies published before February 2016. Fourteen studies involving 
      2,707 participants and 1,131 incident cases were included. The meta-analysis 
      provided evidence of higher peripheral BDNF levels in ASD compared with controls 
      [standardized mean difference (SMD) = 0.63, 95% confidence interval (95% 
      CI) = 0.18-1.08; P = 0.006]. Subgroup analyses revealed higher BDNF levels in ASD 
      compared with controls for both serum [SMD = 0.58, 95% CI = 0.11-1.04; P = 0.02] 
      and plasma [SMD = 1.27, 95% CI = 0.92-1.61; P < 0.001]. Studies of childhood 
      yielded similar cumulative effect size [SMD = 0.78, 95% CI = 0.31-1.26; 
      P = 0.001], while this was not true for the studies of adulthood [SMD = 0.04, 95% 
      CI = -1.72-1.80; P = 0.97]. This meta-analysis suggests that peripheral BDNF 
      levels are a potential biomarker of ASD.
FAU - Zheng, Zhen
AU  - Zheng Z
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
FAU - Zhu, Tingting
AU  - Zhu T
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
FAU - Huang, Jichong
AU  - Huang J
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
FAU - Qu, Yi
AU  - Qu Y
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
FAU - Mu, Dezhi
AU  - Mu D
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China.
AD  - Key Laboratory of Obstetric &Gynecologic and Pediatric Diseases and Birth Defects 
      of Ministry of Education, Sichuan University, Chengdu 610041, China.
AD  - Department of Pediatrics and Neurology, University of California, San Francisco, 
      San Francisco, CA94143, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20160810
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autism Spectrum Disorder/*blood/diagnosis
MH  - Autistic Disorder/*blood/diagnosis
MH  - Biomarkers/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Regression Analysis
MH  - Young Adult
PMC - PMC4979025
EDAT- 2016/08/11 06:00
MHDA- 2018/05/16 06:00
PMCR- 2016/08/10
CRDT- 2016/08/11 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/07/15 00:00 [accepted]
PHST- 2016/08/11 06:00 [entrez]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2016/08/10 00:00 [pmc-release]
AID - srep31241 [pii]
AID - 10.1038/srep31241 [doi]
PST - epublish
SO  - Sci Rep. 2016 Aug 10;6:31241. doi: 10.1038/srep31241.