PMID- 27506653
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20180322
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 314
DP  - 2016 Nov 1
TI  - Ritanserin-sensitive receptors modulate the prosocial and the anxiolytic effect 
      of MDMA derivatives, DOB and PMA, in zebrafish.
PG  - 181-9
LID - S0166-4328(16)30501-0 [pii]
LID - 10.1016/j.bbr.2016.08.009 [doi]
AB  - Little is known about the pharmacological effects of amphetamine derivatives. In 
      the present study, the effect on social preference and anxiety-like behavior of 
      2,5-dimetoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine 
      (PMA), in comparison with 3,4 methylenedioxymethamphetamine (MDMA) was 
      investigated in zebrafish, an emerging model to study emotional behavior in an 
      inexpensive and quick manner. DOB (0.05-2mg/kg), PMA (0.0005-2mg/kg) or MDMA 
      (0.25-20mg/kg), given i.m. to adult zebrafish, progressively increased the time 
      spent in the proximity of nacre fish picture in a social preference test. 
      However, high doses were ineffective. Similarly, in the novel tank diving and 
      light-dark tests the compounds elicited a progressive anxiolytic effect in terms 
      of time spent in the upper half of the tank and in the light compartment, 
      respectively. All the above effects were interpolated by symmetrical parabolas. 
      The 5-HT2A/C antagonist ritanserin (0.025-2.5mg/kg) in association with the 
      maximal effective dose of MDMA, DOB and PMA blocked both the social and 
      anxiolytic effect. Taken together these findings demonstrate for the first time 
      the prosocial and anxiolytic properties of DOB and PMA and focus on the 
      mechanisms of their action through the serotonergic-like system suggesting a 
      potential clinical application.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ponzoni, Luisa
AU  - Ponzoni L
AD  - Fondazione Umberto Veronesi, Milan, Italy; Department of Medical Biotechnology 
      and Translational Medicine (BIOMETRA), Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Sala, Mariaelvina
AU  - Sala M
AD  - Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Milan, 
      Italy. Electronic address: mariaelvina.sala@unimi.it.
FAU - Braida, Daniela
AU  - Braida D
AD  - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), 
      Universita degli Studi di Milano, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160806
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Hallucinogens)
RN  - 145TFV465S (Ritanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Anxiety/drug therapy/psychology
MH  - Behavior, Animal/*drug effects
MH  - Hallucinogens/pharmacology
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Ritanserin/*pharmacology
MH  - Zebrafish
OTO - NOTNLM
OT  - Hallucinogens
OT  - Liokght-dark
OT  - Novel tank
OT  - Social preference
OT  - Zebrafish
EDAT- 2016/08/11 06:00
MHDA- 2018/01/19 06:00
CRDT- 2016/08/11 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/07/30 00:00 [revised]
PHST- 2016/08/04 00:00 [accepted]
PHST- 2016/08/11 06:00 [entrez]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - S0166-4328(16)30501-0 [pii]
AID - 10.1016/j.bbr.2016.08.009 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Nov 1;314:181-9. doi: 10.1016/j.bbr.2016.08.009. Epub 2016 
      Aug 6.