PMID- 27506874
OWN - NLM
STAT- MEDLINE
DCOM- 20171228
LR  - 20220408
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Print)
IS  - 1359-6446 (Linking)
VI  - 21
IP  - 11
DP  - 2016 Nov
TI  - Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki 
      disease.
PG  - 1850-1857
LID - S1359-6446(16)30291-4 [pii]
LID - 10.1016/j.drudis.2016.08.004 [doi]
AB  - Kawasaki disease (KD) is an acute febrile childhood inflammatory disease, 
      associated with coronary artery abnormalities. The disease is believed to result 
      from an aberrant inflammatory response to an infectious trigger in a genetically 
      predisposed individual. KD is associated with an endothelial cell injury as a 
      consequence of T cell activation and cytotoxic effects of various proinflammatory 
      cytokines. Intravenous immunoglobulin (IVIG) infusion and aspirin are the 
      standard treatment of acute KD. However, 10-20% of patients show resistance to 
      IVIG therapy and present higher risk of coronary vasculitis. The relative roles 
      of second IVIG infusion, corticosteroids, calcineurin inhibitors, interleukin-1 
      antagonists and anti-tumor necrosis factor agents remain uncertain. In this 
      review, we highlight the predisposing factors, pathogenesis and therapeutic 
      intervention of KD, particularly new therapeutics for IVIG-resistant patients.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Galeotti, Caroline
AU  - Galeotti C
AD  - Institut National de la Sante et de la Recherche Medicale Unite 1138, Paris 
      F-75006, France; Sorbonne Universites, UPMC Univ Paris 06, UMR S 1138, Paris 
      F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and 
      Therapeutic Immunointervention, Paris F-75006, France; Department of Pediatric 
      Rheumatology, National Referral Centre of Auto-inflammatory Diseases, CHU de 
      Bicetre, le Kremlin Bicetre, University of Paris Sud, F-94270, France.
FAU - Kaveri, Srini V
AU  - Kaveri SV
AD  - Institut National de la Sante et de la Recherche Medicale Unite 1138, Paris 
      F-75006, France; Sorbonne Universites, UPMC Univ Paris 06, UMR S 1138, Paris 
      F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and 
      Therapeutic Immunointervention, Paris F-75006, France; Universite Paris 
      Descartes, Sorbonne Paris Cite, UMR S 1138, Paris F-75006, France.
FAU - Cimaz, Rolando
AU  - Cimaz R
AD  - Anna Meyer Children's Hospital and University of Florence, Florence, Italy.
FAU - Kone-Paut, Isabelle
AU  - Kone-Paut I
AD  - Department of Pediatric Rheumatology, National Referral Centre of 
      Auto-inflammatory Diseases, CHU de Bicetre, le Kremlin Bicetre, University of 
      Paris Sud, F-94270, France.
FAU - Bayry, Jagadeesh
AU  - Bayry J
AD  - Institut National de la Sante et de la Recherche Medicale Unite 1138, Paris 
      F-75006, France; Sorbonne Universites, UPMC Univ Paris 06, UMR S 1138, Paris 
      F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and 
      Therapeutic Immunointervention, Paris F-75006, France; Universite Paris 
      Descartes, Sorbonne Paris Cite, UMR S 1138, Paris F-75006, France. Electronic 
      address: jagadeesh.bayry@crc.jussieu.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160806
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
SB  - IM
MH  - Animals
MH  - Disease Susceptibility
MH  - Humans
MH  - *Mucocutaneous Lymph Node Syndrome/drug therapy/genetics/immunology
MH  - Risk Factors
PMC - PMC7185772
EDAT- 2016/08/11 06:00
MHDA- 2017/12/29 06:00
PMCR- 2016/08/06
CRDT- 2016/08/11 06:00
PHST- 2015/12/14 00:00 [received]
PHST- 2016/06/21 00:00 [revised]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2017/12/29 06:00 [medline]
PHST- 2016/08/11 06:00 [entrez]
PHST- 2016/08/06 00:00 [pmc-release]
AID - S1359-6446(16)30291-4 [pii]
AID - 10.1016/j.drudis.2016.08.004 [doi]
PST - ppublish
SO  - Drug Discov Today. 2016 Nov;21(11):1850-1857. doi: 10.1016/j.drudis.2016.08.004. 
      Epub 2016 Aug 6.