PMID- 27507221
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20180226
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 39
IP  - 1
DP  - 2017 Jan
TI  - Radiotherapy in early-stage tongue squamous cell carcinoma with minor adverse 
      features.
PG  - 147-150
LID - 10.1002/hed.24555 [doi]
AB  - BACKGROUND: Treatment for early-stage tongue squamous cell carcinoma (SCC) is 
      usually surgery alone. There is ambiguity regarding the impact of minor adverse 
      features (MAFs) on outcome and the role of postoperative radiotherapy (PORT) in 
      tongue SCC. METHODS: A retrospective analysis was performed on 48 patients 
      diagnosed with tongue SCC treated in our center. Patients with MAFs received 
      adjuvant PORT. Disease outcome in patients with MAFs, and the effect of PORT were 
      analyzed using the Kaplan-Meier method and log-rank test. RESULTS: Thirty-one 
      patients had T1 and 17 had T2 disease. PORT was given to 7 patients with MAFs. 
      Mean follow-up time was 70 months. The 2-year overall survival (OS) rate was 86%. 
      Perineural invasion had a significant impact on disease-free survival (DFS; p 
      =.05). There was an improved DFS in patients with MAFs treated with PORT (p 
      =.01). CONCLUSION: MAFs may have an impact on outcome in tongue SCC, and PORT can 
      improve disease outcome in these patients. (c) 2016 Wiley Periodicals, Inc. Head 
      Neck 39: 147-150, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Katz, Orna
AU  - Katz O
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center - 
      Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Nachalon, Yuval
AU  - Nachalon Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center - 
      Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Hilly, Ohad
AU  - Hilly O
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center - 
      Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Shpitzer, Thomas
AU  - Shpitzer T
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center - 
      Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Bachar, Gideon
AU  - Bachar G
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center - 
      Beilinson Hospital, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Limon, Dror
AU  - Limon D
AD  - Head and Neck Tumor Unit, Davidoff Cancer Center, Rabin Medical Center, Petach 
      Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Popovtzer, Aron
AU  - Popovtzer A
AD  - Head and Neck Tumor Unit, Davidoff Cancer Center, Rabin Medical Center, Petach 
      Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20160810
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/pathology/*radiotherapy/*surgery
MH  - Female
MH  - Glossectomy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Radiotherapy, Adjuvant
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tongue Neoplasms/pathology/*radiotherapy/*surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - minor adverse features
OT  - oral squamous cell carcinoma
OT  - perineural invasion
OT  - postoperative radiation
OT  - tongue
EDAT- 2016/08/11 06:00
MHDA- 2018/02/24 06:00
CRDT- 2016/08/11 06:00
PHST- 2016/03/21 00:00 [received]
PHST- 2016/06/06 00:00 [revised]
PHST- 2016/06/24 00:00 [accepted]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
PHST- 2016/08/11 06:00 [entrez]
AID - 10.1002/hed.24555 [doi]
PST - ppublish
SO  - Head Neck. 2017 Jan;39(1):147-150. doi: 10.1002/hed.24555. Epub 2016 Aug 10.