PMID- 27508046
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160810
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 8
IP  - 7
DP  - 2016
TI  - Therapeutic effects of human umbilical cord mesenchymal stem cells 
      transplantation on hypoxic ischemic encephalopathy.
PG  - 3241-50
AB  - OBJECTIVE: Human umbilical cord mesenchymal stem cells (hUC-MSCs) hold 
      substantial promise for the treatment of ischemic neurological disease, but few 
      clinical data are currently available about its therapeutic effects in hypoxic 
      ischemic encephalopathy (HIE). This study is to evaluate the effects of hUC-MSCs 
      transplantation on patients with HIE. Methods A total 22 patients with HIEwere 
      randomly divided into hUC-MSCs transplantation group (n = 12) and control group 
      (n = 10). After isolation, hUC-MSCs were cultured for 3 to 5 passages in vitro 
      and then intravenously administered to HIE patients in the transplantation group, 
      while the control group received routine treatment only. The outcomes of HIE 
      patients were evaluated at designated time points by clinical assessment scales, 
      including NIHSS, Barthel Index, MMSE, HAMA24, HAMD14 and UPDRS. RESULTS: hUC-MSCs 
      were identified by morphological analysis and flow cytometry assays before clinic 
      transplantation. No significant differences of demographic characteristics were 
      observed between the two groups of subjects. Compared to the control group, 
      hUC-MSCs transplantation markedly improved the outcomes of HIE patients leading 
      to better recovery of neurological function, cognition ability, emotional 
      reaction and extrapyramidal function. No significant adverse effects were found 
      in subjects with hUC-MSCs transplantation during a 180-day follow-up period. 
      CONCLUSION: These data suggest that hUC-MSCs therapy markedly improves the 
      outcomes of patients with HIE, which is potential for the routine treatment of 
      ischemic neurological disease.
FAU - Xie, Bingchuan
AU  - Xie B
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Gu, Ping
AU  - Gu P
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China; Brain Aging and Cognitive, 
      Neuroscience Laboratory of Hebei ProvinceShijiazhuang 050031, China.
FAU - Wang, Wenting
AU  - Wang W
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Dong, Ci
AU  - Dong C
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Zhang, Lina
AU  - Zhang L
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - The Lab of Cell Therapy, The First Hospital of Hebei Medical University 
      Shijiazhuang 050031, China.
FAU - Liu, Huimiao
AU  - Liu H
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Qiu, Fucheng
AU  - Qiu F
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Han, Rui
AU  - Han R
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Zhang, Zhenqing
AU  - Zhang Z
AD  - Department of Gerontology, The First Hospital of Hebei Medical 
      UniversityShijiazhuang 050031, China; Department of Neurology, The First Hospital 
      of Hebei Medical UniversityShijiazhuang 050031, China.
FAU - Yan, Baoyong
AU  - Yan B
AD  - Brain Aging and Cognitive, Neuroscience Laboratory of Hebei Province Shijiazhuang 
      050031, China.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4969462
OTO - NOTNLM
OT  - Human umbilical cord mesenchymal stem cells
OT  - hypoxic-ischemic encephalopathy
OT  - transplantation
EDAT- 2016/08/11 06:00
MHDA- 2016/08/11 06:01
PMCR- 2016/07/15
CRDT- 2016/08/11 06:00
PHST- 2016/03/14 00:00 [received]
PHST- 2016/05/19 00:00 [accepted]
PHST- 2016/08/11 06:00 [entrez]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2016/08/11 06:01 [medline]
PHST- 2016/07/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2016 Jul 15;8(7):3241-50. eCollection 2016.