PMID- 27508345
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 9
IP  - 7
DP  - 2017 Jul
TI  - Hyperglycemia is associated with increased risk of patient delay in pulmonary 
      tuberculosis in rural areas.
PG  - 648-655
LID - 10.1111/1753-0407.12459 [doi]
AB  - BACKGROUND: Excessive time between the first presentation of symptoms of 
      pulmonary tuberculosis (PTB) and diagnosis contributes to ongoing transmission 
      and increased risk of infection in the community, as well as to increased disease 
      severity and higher mortality. People with type 2 diabetes mellitus (T2DM) have a 
      higher risk of developing PTB. However, the effect of T2DM on delayed diagnosis 
      of PTB is not fully understood. This study investigated the effects of 
      hyperglycemia (diabetes and prediabetes) and other factors on PTB patient delay 
      in a rural area of China. METHODS: In the present community-based investigation, 
      PTB patients aged >/=16 years newly diagnosed at county tuberculosis dispensaries 
      were recruited consecutively between September 2011 and December 2013. Fasting 
      blood glucose was determined in all subjects, and a structured questionnaire was 
      used to collect basic information. RESULTS: Of the 2280 patients, 605 (26.5 %) 
      had hyperglycemia. The median (interquartile range) time to seeking health care 
      was 44 (59) days. Health care seeking was delayed in 1754 subjects, and 
      hyperglycemia was independently associated with an increased probability (odds 
      ratio 2.10; 95 % confidence interval 1.49-2.97) of patient delay in subjects aged 
      >/=30 years. Other factors associated with patient delay were cough, night sweats, 
      and lack of knowledge regarding typical tuberculosis symptoms. The onset of 
      hemoptysis was negatively correlated with patient delay. CONCLUSIONS: Patient 
      delay appears to be a serious problem in this rural area with a high prevalence 
      of tuberculosis. Hyperglycemia is independently associated with an increased 
      probability of patient delay, which, in turn, may result in more serious clinical 
      manifestations.
CI  - (c) 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Wang, Qiuzhen
AU  - Wang Q
AD  - Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 
      China.
FAU - Ma, Aiguo
AU  - Ma A
AD  - Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 
      China.
FAU - Han, Xiuxia
AU  - Han X
AD  - Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 
      China.
FAU - Zhao, Shanliang
AU  - Zhao S
AD  - Linyi Chest Hospital, Linyi, China.
FAU - Cai, Jing
AU  - Cai J
AD  - Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 
      China.
FAU - Kok, Frans J
AU  - Kok FJ
AD  - Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
FAU - Schouten, Evert G
AU  - Schouten EG
AD  - Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Blood Glucose
MH  - China
MH  - Cross-Sectional Studies
MH  - Delayed Diagnosis
MH  - Diabetes Mellitus, Type 2/blood/ethnology
MH  - Fasting/blood/metabolism
MH  - Female
MH  - Humans
MH  - Hyperglycemia/*blood/ethnology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood/ethnology
MH  - Risk Factors
MH  - Rural Population/*statistics & numerical data
MH  - Tuberculosis, Pulmonary/*blood/diagnosis/ethnology
OTO - NOTNLM
OT  - community
OT  - determining factor
OT  - diabetes mellitus
OT  - infectious disease
OT  - odds ratio
OT  - 优势比
OT  - 传染病
OT  - 决定因素
OT  - 社区
OT  - 糖尿病
EDAT- 2016/08/11 06:00
MHDA- 2018/03/20 06:00
CRDT- 2016/08/11 06:00
PHST- 2016/04/08 00:00 [received]
PHST- 2016/07/12 00:00 [revised]
PHST- 2016/08/07 00:00 [accepted]
PHST- 2016/08/11 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2016/08/11 06:00 [entrez]
AID - 10.1111/1753-0407.12459 [doi]
PST - ppublish
SO  - J Diabetes. 2017 Jul;9(7):648-655. doi: 10.1111/1753-0407.12459. Epub 2016 Sep 
      20.