PMID- 27508959 OWN - NLM STAT- MEDLINE DCOM- 20180102 LR - 20180217 IS - 2191-0200 (Electronic) IS - 0334-1763 (Linking) VI - 27 IP - 8 DP - 2016 Dec 1 TI - Brain-derived neurotrophic factor: a mediator of inflammation-associated neurogenesis in Alzheimer's disease. PG - 793-811 LID - 10.1515/revneuro-2016-0017 [doi] AB - In early- or late-onset Alzheimer's disease (AD), inflammation, which is triggered by pathologic conditions, influences the progression of neurodegeneration. Brain-derived neurotrophic factor (BDNF) has emerged as a crucial mediator of neurogenesis, because it exhibits a remarkable activity-dependent regulation of expression, which suggests that it may link inflammation to neurogenesis. Emerging evidence suggests that acute and chronic inflammation in AD differentially modulates neurotrophin functions, which are related to the roles of inflammation in neuroprotection and neurodegeneration. Recent studies also indicate novel mechanisms of BDNF-mediated neuroprotection, including the modulation of autophagy. Numerous research studies have demonstrated reverse parallel alterations between proinflammatory cytokines and BDNF during neurodegeneration; thus, we hypothesize that one mechanism that underlies the negative impact of chronic inflammation on neurogenesis is the reduction of BDNF production and function by proinflammatory cytokines. FAU - Chen, Jian-Jiao AU - Chen JJ FAU - Wang, Tao AU - Wang T FAU - An, Cai-di AU - An CD FAU - Jiang, Chun-Yan AU - Jiang CY FAU - Zhao, Jie AU - Zhao J FAU - Li, Shao AU - Li S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Germany TA - Rev Neurosci JT - Reviews in the neurosciences JID - 8711016 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cytokines) SB - IM MH - Alzheimer Disease/*metabolism/therapy MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cytokines/*metabolism MH - Humans MH - Inflammation/*metabolism MH - Neurogenesis/*physiology MH - Neurons/metabolism EDAT- 2016/08/11 06:00 MHDA- 2018/01/03 06:00 CRDT- 2016/08/11 06:00 PHST- 2016/04/11 00:00 [received] PHST- 2016/05/29 00:00 [accepted] PHST- 2016/08/11 06:00 [pubmed] PHST- 2018/01/03 06:00 [medline] PHST- 2016/08/11 06:00 [entrez] AID - /j/revneuro.ahead-of-print/revneuro-2016-0017/revneuro-2016-0017.xml [pii] AID - 10.1515/revneuro-2016-0017 [doi] PST - ppublish SO - Rev Neurosci. 2016 Dec 1;27(8):793-811. doi: 10.1515/revneuro-2016-0017.