PMID- 2750922
OWN - NLM
STAT- MEDLINE
DCOM- 19890816
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 257
IP  - 1 Pt 2
DP  - 1989 Jul
TI  - Colloid osmotic pressure in young analbuminemic rats.
PG  - F23-8
AB  - Colloid osmotic pressure (COP) was measured in plasma and interstitial fluid 
      (subcutaneous wick) from 8 to 75 days of age in Nagase analbuminemic rats (NAR) 
      and control Sprague-Dawley rats (SDR). In all animals plasma COP (approximately 
      10 mmHg at 8 days of age) increased during growth. In the female NAR the rise in 
      nonalbumin proteins was so large that at 75 days the plasma COP was not lower 
      than in the SDR; whereas in male NAR a difference of approximately 4 mmHg 
      remained. Interstitial COP increased with aging in the SDR, but not in the NAR. 
      This resulted in equal transcapillary COP gradients in 75-day-old male and female 
      SDR and male NAR (approximately 11-12 mmHg) but a somewhat larger gradient in the 
      female NAR (approximately 14 mmHg). Blood pressure and plasma volume were not low 
      in the NAR. Extracellular fluid volume (as a percentage of body weight) was 
      similar in all groups and decreased with age. Clearances of 51Cr-labeled EDTA and 
      125I-labeled hippuric acid were decreased in young (45 day) NAR vs. young SDR, 
      but not at 75 days of age. In conclusion, NAR are able to maintain a normal 
      transcapillary COP gradient, and do not display signs of abnormal volume 
      regulation during early development.
FAU - Joles, J A
AU  - Joles JA
AD  - Department of Nephrology and Hypertension, Medical Faculty, University of 
      Utrecht, The Netherlands.
FAU - Willekes-Koolschijn, N
AU  - Willekes-Koolschijn N
FAU - Braam, B
AU  - Braam B
FAU - Kortlandt, W
AU  - Kortlandt W
FAU - Koomans, H A
AU  - Koomans HA
FAU - Dorhout Mees, E J
AU  - Dorhout Mees EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Proteins)
RN  - 0 (Colloids)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Blood Proteins/analysis
MH  - Body Weight
MH  - Colloids
MH  - Extracellular Space/physiology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Male
MH  - Osmotic Pressure
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Renal Circulation
MH  - Serum Albumin/analysis/*deficiency
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.1152/ajprenal.1989.257.1.F23 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Jul;257(1 Pt 2):F23-8. doi: 10.1152/ajprenal.1989.257.1.F23.