PMID- 27511600
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20231213
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Aug 11
TI  - The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous 
      Clearance Are Independent of IL28B in the Chinese Population.
PG  - 31485
LID - 10.1038/srep31485 [doi]
LID - 31485
AB  - Spontaneous clearance of hepatitis C virus (HCV) occurs in 10-40% of the 
      infections. Specific human leukocyte antigen (HLA) alleles have been identified 
      in associating with HCV clearance. However, data on the association of HLA with 
      the spontaneous clearance of HCV are scarce in the Chinese population. In the 
      current study we studied the HLA class I and class II genes in 231 Chinese 
      voluntary blood donors who had cleared HCV infection spontaneously compared to 
      429 subjects with chronic HCV infections. We also studied their IL28B SNP 
      (rs8099917) genotype, since a number of investigators have found a strong 
      association of IL28B with spontaneous or treatment induced HCV clearance. We 
      found that HLA-A*02:01 and DQB1*05:02 distributed differently between the two 
      groups after Bonferroni correction (odds ratio [OR] = 1.839, Pc = 0.024 and 
      OR = 0.547, Pc = 0.016, respectively). Multivariate logistic regression analysis 
      suggested that A*02:01 and DRB1*11:01 (OR = 1.798, P = 0.008 and OR = 1.921, 
      P = 0.005, respectively) were associated with HCV spontaneous clearance, 
      independent of age, gender and IL28B polymorphism. We concluded that in the 
      Chinese population, HLA-A*02:01 and DRB1*11:01 might be associated with the host 
      capacity to clear HCV independent of IL28B, which suggesting that the innate and 
      adaptive immune responses both play an important role in the control of HCV.
FAU - Huang, Jieting
AU  - Huang J
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Huang, Ke
AU  - Huang K
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Xu, Ru
AU  - Xu R
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Wang, Min
AU  - Wang M
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Liao, Qiao
AU  - Liao Q
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Xiong, Huaping
AU  - Xiong H
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Li, Chengyao
AU  - Li C
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Tang, Xi
AU  - Tang X
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Shan, Zhengang
AU  - Shan Z
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Epidemiology and Biostatistics, Faculty of Infectious Diseases, 
      University of Georgia, Athens, GA, USA.
FAU - Rong, Xia
AU  - Rong X
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
FAU - Nelson, Kenrad
AU  - Nelson K
AD  - Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins 
      University, Baltimore, Maryland, USA.
FAU - Fu, Yongshui
AU  - Fu Y
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Disciplines and Specialties Program of Guangzhou, Guangdong, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160811
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA-A Antigens)
RN  - 0 (interferon-lambda, human)
RN  - 0 (Interleukins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RBM45 protein, human)
RN  - 0 (RNA-Binding Proteins)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Female
MH  - Genetic Association Studies
MH  - HLA-A Antigens/*genetics
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/*genetics
MH  - Humans
MH  - Interferons
MH  - Interleukins/*genetics
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - RNA-Binding Proteins/*genetics
MH  - Young Adult
PMC - PMC4980596
EDAT- 2016/08/12 06:00
MHDA- 2018/05/09 06:00
PMCR- 2016/08/11
CRDT- 2016/08/12 06:00
PHST- 2016/03/05 00:00 [received]
PHST- 2016/07/20 00:00 [accepted]
PHST- 2016/08/12 06:00 [entrez]
PHST- 2016/08/12 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2016/08/11 00:00 [pmc-release]
AID - srep31485 [pii]
AID - 10.1038/srep31485 [doi]
PST - epublish
SO  - Sci Rep. 2016 Aug 11;6:31485. doi: 10.1038/srep31485.