PMID- 27512437
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160811
LR  - 20201001
IS  - 1753-495X (Print)
IS  - 1753-4968 (Electronic)
IS  - 1753-495X (Linking)
VI  - 7
IP  - 3
DP  - 2014 Sep
TI  - Pregnancy in multiple endocrine neoplasia type 1 equals multiple complications.
PG  - 123-5
LID - 10.1177/1753495X14532634 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is a rare inherited disorder caused 
      by mutations in the tumour suppressor gene MEN 1. It is characterised by a 
      predisposition towards the development of parathyroid, anterior pituitary and 
      entero-pancreatic tumours. Clinically, MEN 1 is defined following development of 
      two out of these three tumours. There have been no published cases of the 
      management of MEN 1 in pregnancy. We report the first case of a 31-year-old 
      primigravida with a confirmed diagnosis of MEN 1 prior to conception. Due to the 
      rare nature of MEN 1, there are no guidelines on how such women should be 
      managed. The main issues were to assess and manage potential complications, such 
      as hypercalcaemia, diabetes mellitus and the symptoms from a pituitary tumour as 
      well the issues around a gastrinoma and monitor fetal well-being. A Caesarean 
      section was performed at 35 weeks gestation for a growth-restricted fetus with 
      raised umbilical artery Dopplers. The neonate was treated with intravenous 
      calcium secondary to hypocalcaemia. The patient and neonate recovered well. We 
      have demonstrated successful management of a woman with MEN 1 who completed her 
      pregnancy with few complications and a healthy neonate. It is vital for such 
      women to be managed in the context of a multidisciplinary team setting to 
      optimise maternal and fetal outcomes.
FAU - Mistry, Megha
AU  - Mistry M
AD  - Department of Obstetrics and Gynaecology, Barts Health, Whipps Cross University 
      Hospital, London, UK.
FAU - Gupta, Manish
AU  - Gupta M
AD  - Department of Obstetrics and Gynaecology, Barts Health, Whipps Cross University 
      Hospital, London, UK.
FAU - Kaler, Mandeep
AU  - Kaler M
AD  - Department of Obstetrics and Gynaecology, Barts Health, Whipps Cross University 
      Hospital, London, UK.
LA  - eng
PT  - Case Reports
DEP - 20140506
PL  - England
TA  - Obstet Med
JT  - Obstetric medicine
JID - 101464191
PMC - PMC4934976
OTO - NOTNLM
OT  - Endocrinology
OT  - high-risk pregnancy
OT  - maternal-fetal medicine
EDAT- 2014/09/01 00:00
MHDA- 2014/09/01 00:01
PMCR- 2014/09/01
CRDT- 2016/08/12 06:00
PHST- 2016/08/12 06:00 [entrez]
PHST- 2014/09/01 00:00 [pubmed]
PHST- 2014/09/01 00:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1177_1753495X14532634 [pii]
AID - 10.1177/1753495X14532634 [doi]
PST - ppublish
SO  - Obstet Med. 2014 Sep;7(3):123-5. doi: 10.1177/1753495X14532634. Epub 2014 May 6.