PMID- 27512511
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160811
LR  - 20201001
IS  - 1817-1737 (Print)
IS  - 1998-3557 (Electronic)
IS  - 1998-3557 (Linking)
VI  - 11
IP  - 3
DP  - 2016 Jul-Sep
TI  - Association of human leukocyte antigen class II alleles with severe Middle East 
      respiratory syndrome-coronavirus infection.
PG  - 211-3
LID - 10.4103/1817-1737.185756 [doi]
AB  - BACKGROUND: Middle East Respiratory Syndrome (MERS) is a disease of the lower 
      respiratory tract and is characterized by high mortality. It is caused by a beta 
      coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been 
      reported from Saudi Arabia. AIM: We investigated the human leukocyte antigen 
      (HLA) Class II alleles in patients with severe MERS who were admitted in our 
      Intensive Care Unit. METHODS: A total of 23 Saudi patients with severe MERS-CoV 
      infection were typed for HLA class II, results were compared with those of 161 
      healthy controls. RESULTS: Two HLA class II alleles were associated with the 
      disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome. 
      CONCLUSIONS: Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be 
      associated with susceptibility to MERS.
FAU - Hajeer, Ali H
AU  - Hajeer AH
AD  - Department of Basic Medical Sciences, King Saud bin Abdulaziz University for 
      Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia; Department of 
      Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, 
      King Abdulaziz Medical City, Riyadh, Saudi Arabia.
FAU - Balkhy, Hanan
AU  - Balkhy H
AD  - Department of Infection Prevention and Control, King Saud bin Abdulaziz 
      University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi 
      Arabia; King Abdullah International Medical Research Center, King Abdulaziz 
      Medical City, Riyadh, Saudi Arabia.
FAU - Johani, Sameera
AU  - Johani S
AD  - Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for 
      Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
FAU - Yousef, Mohammed Z
AU  - Yousef MZ
AD  - Department of Basic Medical Sciences, King Saud bin Abdulaziz University for 
      Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
FAU - Arabi, Yaseen
AU  - Arabi Y
AD  - King Abdullah International Medical Research Center, King Abdulaziz Medical City, 
      Riyadh, Saudi Arabia; Department of Intensive Care, King Abdulaziz Medical City, 
      Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Thorac Med
JT  - Annals of thoracic medicine
JID - 101280721
PMC - PMC4966224
OTO - NOTNLM
OT  - Human leukocyte Antigen Class II
OT  - Middle East respiratory syndrome-coronavirus
OT  - Saudi Arabia
EDAT- 2016/08/12 06:00
MHDA- 2016/08/12 06:01
PMCR- 2016/07/01
CRDT- 2016/08/12 06:00
PHST- 2016/08/12 06:00 [entrez]
PHST- 2016/08/12 06:00 [pubmed]
PHST- 2016/08/12 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - ATM-11-211 [pii]
AID - 10.4103/1817-1737.185756 [doi]
PST - ppublish
SO  - Ann Thorac Med. 2016 Jul-Sep;11(3):211-3. doi: 10.4103/1817-1737.185756.