PMID- 27512990
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 8
DP  - 2016
TI  - Altered Vision-Related Resting-State Activity in Pituitary Adenoma Patients with 
      Visual Damage.
PG  - e0160119
LID - 10.1371/journal.pone.0160119 [doi]
LID - e0160119
AB  - OBJECTIVE: To investigate changes of vision-related resting-state activity in 
      pituitary adenoma (PA) patients with visual damage through comparison to healthy 
      controls (HCs). METHODS: 25 PA patients with visual damage and 25 age- and 
      sex-matched corrected-to-normal-vision HCs underwent a complete 
      neuro-ophthalmologic evaluation, including automated perimetry, fundus 
      examinations, and a magnetic resonance imaging (MRI) protocol, including 
      structural and resting-state fMRI (RS-fMRI) sequences. The regional homogeneity 
      (ReHo) of the vision-related cortex and the functional connectivity (FC) of 6 
      seeds within the visual cortex (the primary visual cortex (V1), the secondary 
      visual cortex (V2), and the middle temporal visual cortex (MT+)) were evaluated. 
      Two-sample t-tests were conducted to identify the differences between the two 
      groups. RESULTS: Compared with the HCs, the PA group exhibited reduced ReHo in 
      the bilateral V1, V2, V3, fusiform, MT+, BA37, thalamus, postcentral gyrus and 
      left precentral gyrus and increased ReHo in the precuneus, prefrontal cortex, 
      posterior cingulate cortex (PCC), anterior cingulate cortex (ACC), insula, 
      supramarginal gyrus (SMG), and putamen. Compared with the HCs, V1, V2, and MT+ in 
      the PAs exhibited decreased FC with the V1, V2, MT+, fusiform, BA37, and 
      increased FC primarily in the bilateral temporal lobe (especially BA20,21,22), 
      prefrontal cortex, PCC, insular, angular gyrus, ACC, pre-SMA, SMG, hippocampal 
      formation, caudate and putamen. It is worth mentioning that compared with HCs, V1 
      in PAs exhibited decreased or similar FC with the thalamus, whereas V2 and MT+ 
      exhibited increased FCs with the thalamus, especially pulvinar. CONCLUSIONS: In 
      our study, we identified significant neural reorganization in the vision-related 
      cortex of PA patients with visual damage compared with HCs. Most subareas within 
      the visual cortex exhibited remarkable neural dysfunction. Some subareas, 
      including the MT+ and V2, exhibited enhanced FC with the thalamic pulvinar, which 
      indicates an important role in the compensatory mechanism following visual 
      impairment. In addition, neural dysfunction within the visual cortex was 
      associated with neural activity alternation in the higher-order cognitive cortex, 
      especially subareas in default mode network (DMN) and salience network (SN).
FAU - Qian, Haiyan
AU  - Qian H
AD  - Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital 
      Medical University, Beijing, China.
AD  - Beijing Neurosurgery Institute, Capital Medical University affiliated to Capital 
      Medical University, Beijing, China.
FAU - Wang, Xingchao
AU  - Wang X
AD  - Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital 
      Medical University, Beijing, China.
FAU - Wang, Zhongyan
AU  - Wang Z
AD  - Department of Radiology, Beijing Tiantan Hospital affiliated to Capital Medical 
      University, Beijing, China.
FAU - Wang, Zhenmin
AU  - Wang Z
AD  - Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital 
      Medical University, Beijing, China.
FAU - Liu, Pinan
AU  - Liu P
AD  - Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital 
      Medical University, Beijing, China.
AD  - Beijing Neurosurgery Institute, Capital Medical University affiliated to Capital 
      Medical University, Beijing, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160811
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adenoma/*pathology
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cognition Disorders/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*pathology
MH  - Pituitary Neoplasms/*pathology
MH  - *Rest
MH  - Vision Disorders/*physiopathology
MH  - Visual Cortex/*pathology
MH  - Visual Fields
MH  - Young Adult
PMC - PMC4981336
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/08/12 06:00
MHDA- 2017/07/28 06:00
PMCR- 2016/08/11
CRDT- 2016/08/12 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/08/12 06:00 [entrez]
PHST- 2016/08/12 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
PHST- 2016/08/11 00:00 [pmc-release]
AID - PONE-D-16-10858 [pii]
AID - 10.1371/journal.pone.0160119 [doi]
PST - epublish
SO  - PLoS One. 2016 Aug 11;11(8):e0160119. doi: 10.1371/journal.pone.0160119. 
      eCollection 2016.