PMID- 27514572
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20180816
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Linking)
VI  - 54
DP  - 2016 Aug
TI  - Association of testosterone and BDNF serum levels with craving during alcohol 
      withdrawal.
PG  - 67-72
LID - S0741-8329(16)30034-9 [pii]
LID - 10.1016/j.alcohol.2016.06.004 [doi]
AB  - Preclinical and clinical studies show associations between testosterone and 
      brain-derived neurotrophic growth factor (BDNF) serum levels. BDNF and 
      testosterone have been independently reported to influence alcohol consumption. 
      Therefore, we aimed to investigate a possible interplay of testosterone and BDNF 
      contributing to alcohol dependence. Regarding possible interplay of testosterone 
      and BDNF and the activity of the hypothalamic pituitary axis (HPA), we included 
      cortisol serum levels in our research. We investigated testosterone and BDNF 
      serum levels in a sample of 99 male alcohol-dependent patients during alcohol 
      withdrawal (day 1, 7, and 14) and compared them to a healthy male control group 
      (n = 17). The testosterone serum levels were significantly (p < 0.001) higher in 
      the patients' group than in the control group and decreased significantly during 
      alcohol withdrawal (p < 0.001). The decrease of testosterone serum levels during 
      alcohol withdrawal (days 1-7) was significantly associated with the BDNF serum 
      levels (day 1: p = 0.008). In a subgroup of patients showing high cortisol serum 
      levels (putatively mirroring high HPA activity), we found a significant 
      association of BDNF and testosterone as well as with alcohol craving measured by 
      the Obsessive and Compulsive Drinking Scale (OCDS). Our data suggest a possible 
      association of BDNF and testosterone serum levels, which may be relevant for the 
      symptomatology of alcohol dependence. Further studies are needed to clarify our 
      results.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Heberlein, Annemarie
AU  - Heberlein A
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany; Fachklinikum Uchtspringe, 
      Emil-Kraepelin-Str. 6, 39576 Stendal, Germany. Electronic address: 
      a.heberlein@salus-lsa.de.
FAU - Lenz, Bernd
AU  - Lenz B
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg, Germany.
FAU - Opfermann, Birgitt
AU  - Opfermann B
AD  - Medizinischer Dienst der Krankenversicherungen Niedersachsen, Hildesheimer Str. 
      265-267, 30519 Hannover, Germany.
FAU - Groschl, Michael
AU  - Groschl M
AD  - Bioanalytical Laboratory, Celerion Switzerland AG, Allmendstr. 32, 8320 
      Fehraltorf, Switzerland.
FAU - Janke, Eva
AU  - Janke E
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
FAU - Stange, Katrin
AU  - Stange K
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
FAU - Groh, Adrian
AU  - Groh A
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
FAU - Kornhuber, Johannes
AU  - Kornhuber J
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg, Germany.
FAU - Frieling, Helge
AU  - Frieling H
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
FAU - Bleich, Stefan
AU  - Bleich S
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
FAU - Hillemacher, Thomas
AU  - Hillemacher T
AD  - Center for Addiction Research (CARe), Department of Psychiatry, Social Psychiatry 
      and Psychotherapy, Medical School Hanover, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160721
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3XMK78S47O (Testosterone)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Alcohol-Induced Disorders/*blood/complications
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - *Craving
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Substance Withdrawal Syndrome/*blood/complications
MH  - Testosterone/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Abstinence
OT  - Alcohol dependence
OT  - Alcohol withdrawal
OT  - BDNF
OT  - Testosterone
EDAT- 2016/08/16 06:00
MHDA- 2017/12/13 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/02/14 00:00 [received]
PHST- 2016/06/14 00:00 [revised]
PHST- 2016/06/14 00:00 [accepted]
PHST- 2016/08/13 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
AID - S0741-8329(16)30034-9 [pii]
AID - 10.1016/j.alcohol.2016.06.004 [doi]
PST - ppublish
SO  - Alcohol. 2016 Aug;54:67-72. doi: 10.1016/j.alcohol.2016.06.004. Epub 2016 Jul 21.