PMID- 27515290
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20180816
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 314
DP  - 2016 Nov 1
TI  - Helium preconditioning protects the brain against hypoxia/ischemia injury via 
      improving the neurovascular niche in a neonatal rat model.
PG  - 165-72
LID - S0166-4328(16)30507-1 [pii]
LID - 10.1016/j.bbr.2016.08.015 [doi]
AB  - This study aimed to investigate whether helium preconditioning (He-PC) is able to 
      exert neuroprotective effects via improving focal neurovascular niche in a 
      neonatal rat hypoxia/ischemia (HI) brain injury model. Seven day old rat pups 
      were divided into control group, HI group and He-PC group. HI was induced by 
      exposure to 8% oxygen for 90min one day after preconditioning with 70% helium-30% 
      oxygen for three 5-min periods. At 3 and 7 days, the brain was collected for the 
      detection of inflammation related factors (tumor necrosis factor alpha [TNF-alpha], 
      interleukin-1beta [IL-1beta], IL-10) and growth/neurotrophic factors (brain-derived 
      neurotrophic factor [BDNF], basic fibroblast growth factor [bFGF] and nerve 
      growth factor [NGF]); at 7 days, neurobehaviors were evaluated, and the brain was 
      collected for the detection of mRNA expression of vascular endothelial growth 
      factor (VEGF) and angiopoietin-1 (Ang-1) by PCR, protein expression of 
      angiogenesis related molecules (VEGF, Ang-1, Tie-2 and Flt-1) by Western blotting 
      and microvessel density (MCD) by immunohistochemistry for vWF. Results showed 
      He-PC was able to reduce TNF-alpha and IL-1beta, further increase IL-10, BDNF, bFGF and 
      NGF, elevate the mRNA expression of VEGF and Ang-1, increase the protein 
      expression of VEGF, Ang-1, Tie-2 and Flt-1, promote angiogenesis and improve 
      neurobehaviors as compared to HI group. These findings suggest that He-PC may 
      improve the post-stroke neurovascular niche to exert neuroprotective effects on 
      neonatal HI brain injury.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School 
      of Medicine, No 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China.
FAU - Zhang, Peixi
AU  - Zhang P
AD  - Department of Cardiothoracic Surgery, The First Hospital of Jining City, No 6, 
      Jiankang Road, Jining City, Shandong 272011, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Pathology, Yantaishan Hospital, No 91, Jiefang Road, Zhifu 
      District, Yantai City, Shandong 264001, China.
FAU - Liu, Wenwu
AU  - Liu W
AD  - Department of Diving and Hyperbaric Medicine, The Second Military Medical 
      University, Shanghai, China. Electronic address: liuwenwu1980@hotmail.com.
FAU - Yin, Na
AU  - Yin N
AD  - Department of Anesthesiology & Critical Care Medicine, Xin Hua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, 
      China. Electronic address: anne_yin2016@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 206GF3GB41 (Helium)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Helium/*pharmacology
MH  - Hypoxia-Ischemia, Brain/*pathology
MH  - Ischemic Preconditioning/methods
MH  - Neuroprotective Agents/pharmacology
MH  - Rats
OTO - NOTNLM
OT  - Angiogenesis
OT  - Growth factor
OT  - Helium preconditioning
OT  - Inflammation
OT  - Neurobehaviors
EDAT- 2016/08/16 06:00
MHDA- 2018/01/19 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/07/26 00:00 [received]
PHST- 2016/08/03 00:00 [revised]
PHST- 2016/08/07 00:00 [accepted]
PHST- 2016/08/13 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
AID - S0166-4328(16)30507-1 [pii]
AID - 10.1016/j.bbr.2016.08.015 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Nov 1;314:165-72. doi: 10.1016/j.bbr.2016.08.015. Epub 2016 
      Aug 8.