PMID- 27516133
OWN - NLM
STAT- MEDLINE
DCOM- 20170118
LR  - 20170118
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 65
IP  - 4
DP  - 2016 Oct
TI  - Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in 
      patients with allergic rhinitis.
PG  - 396-399
LID - S1323-8930(16)30031-4 [pii]
LID - 10.1016/j.alit.2016.03.009 [doi]
AB  - BACKGROUND: Studies show that immunoglobulin E (IgE) is produced in the local 
      nasal mucosa in allergic rhinitis patients. However, no study involved the 
      measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis 
      patients. This study aimed to measure the local IgE levels in the nasal mucosal 
      tissue and to compare the levels of total IgE and specific IgEs in the serum and 
      the inferior turbinate nasal mucosa in allergic rhinitis patients using the 
      AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany). 
      METHODS: Total IgE antibodies and allergen-specific IgE antibodies in each sample 
      of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the 
      AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific 
      for house dust (HD), mites, and cedar pollen in the serum and the inferior 
      turbinate. RESULTS: The total IgE levels and the cedar pollen-specific IgE levels 
      in the inferior turbinate mucosal tissue correlated significantly with their 
      respective levels in serum. The HD- and mite-specific IgE levels in the inferior 
      turbinate mucosal tissue did not correlate significantly with their respective 
      levels in the serum. CONCLUSIONS: Our results evaluating the correlations between 
      nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced 
      in the nasal mucosa affects the IgE levels in the serum, especially the cedar 
      pollen-specific IgE.
CI  - Copyright (c) 2016 Japanese Society of Allergology. Production and hosting by 
      Elsevier B.V. All rights reserved.
FAU - Ota, Yasushi
AU  - Ota Y
AD  - Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, 
      Japan. Electronic address: yasushiota5610@yahoo.co.jp.
FAU - Ikemiyagi, Yoshihiro
AU  - Ikemiyagi Y
AD  - Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, 
      Japan.
FAU - Sato, Toshiya
AU  - Sato T
AD  - Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, 
      Japan.
FAU - Funakoshi, Tatsuo
AU  - Funakoshi T
AD  - CAI Business Unit, Siemens Healthcare Diagnostics K.K., Tokyo, Japan.
FAU - Hiruta, Nobuyuki
AU  - Hiruta N
AD  - Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
FAU - Kitamura, Makoto
AU  - Kitamura M
AD  - Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
FAU - Bujo, Hideaki
AU  - Bujo H
AD  - Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, 
      Japan.
FAU - Suzuki, Mitsuya
AU  - Suzuki M
AD  - Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Biomarkers
MH  - Eosinophils/immunology/physiology
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Leukocyte Count
MH  - Nasal Mucosa/*immunology
MH  - Rhinitis, Allergic/*diagnosis/*immunology
MH  - *Turbinates
OTO - NOTNLM
OT  - AlaSTAT 3gAllergy assay
OT  - Cedar pollen
OT  - House dust
OT  - Local allergic rhinitis
OT  - Mites
EDAT- 2016/08/16 06:00
MHDA- 2017/01/19 06:00
CRDT- 2016/08/13 06:00
PHST- 2015/09/01 00:00 [received]
PHST- 2016/02/18 00:00 [revised]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/01/19 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - S1323-8930(16)30031-4 [pii]
AID - 10.1016/j.alit.2016.03.009 [doi]
PST - ppublish
SO  - Allergol Int. 2016 Oct;65(4):396-399. doi: 10.1016/j.alit.2016.03.009. Epub 2016 
      Aug 8.