PMID- 27516136
OWN - NLM
STAT- MEDLINE
DCOM- 20170803
LR  - 20170817
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 29
IP  - 11
DP  - 2016 Nov
TI  - The association between killer-cell immunoglobulin-like receptor (KIR) and KIR 
      ligand genotypes and the likelihood of BK virus replication after kidney 
      transplantation.
PG  - 1168-1175
LID - 10.1111/tri.12820 [doi]
AB  - BK virus is a common opportunistic post-transplantation viral infection. Although 
      some risk factors have been studied in this context, the contribution of NK cells 
      has not been assessed in detail. In a group of kidney transplant recipients, we 
      studied the association between (i) the likelihood of BK virus replication during 
      the two-year period after kidney transplantation and (ii) the genotypes of the 
      killer cell immunoglobulin-like receptor (KIR) repertoire and their human 
      leukocyte antigen (HLA) ligands. Other clinical factors (such as defective organ 
      recovery and immunosuppressive treatment) were also assessed. BK virus 
      replication was observed in 43 of the 103 recipients (41%). Patients with BK 
      virus replication in the plasma were more likely to display defective organ 
      recovery in the first seven days post-transplantation. BK virus replication was 
      not associated with Missing KIR ligands. However, BK virus replication was more 
      frequent in patients with responsive NK cells (i.e. when a ligand for activating 
      KIRs was not homozygous in the recipient and present in the donor). Our results 
      suggest that defective organ recovery and the recipient's activating KIR 
      repertoire may be related (depending on HLA ligands present in the couple 
      recipient / donor) to the reactivation of BK virus replication after kidney 
      transplantation.
CI  - (c) 2016 Steunstichting ESOT.
FAU - Brochot, Etienne
AU  - Brochot E
AD  - Virology Research Unit, EA 4294, Jules Verne University of Picardie, Amiens, 
      France.
AD  - Department of Virology, Amiens University Medical Center, Amiens, France.
FAU - Desoutter, Judith
AU  - Desoutter J
AD  - Department of Histocompatibility, Amiens University Medical Center, Amiens, 
      France.
AD  - EA 4666, Jules Verne University of Picardie, Amiens, France.
FAU - Presne, Claire
AU  - Presne C
AD  - Department of Nephrology Dialysis Transplantation, Amiens University Medical 
      Center, Amiens, France.
AD  - INSERM 1088, Jules Verne University of Picardie, Amiens, France.
FAU - De Araujo, Isabelle
AU  - De Araujo I
AD  - Department of Histocompatibility, Amiens University Medical Center, Amiens, 
      France.
AD  - EA 4666, Jules Verne University of Picardie, Amiens, France.
FAU - Flahaut, Gauthier
AU  - Flahaut G
AD  - Department of Nephrology Dialysis Transplantation, Amiens University Medical 
      Center, Amiens, France.
AD  - INSERM 1088, Jules Verne University of Picardie, Amiens, France.
FAU - Castelain, Sandrine
AU  - Castelain S
AD  - Virology Research Unit, EA 4294, Jules Verne University of Picardie, Amiens, 
      France.
AD  - Department of Virology, Amiens University Medical Center, Amiens, France.
FAU - Westeel, Pierre-Francois
AU  - Westeel PF
AD  - Department of Nephrology Dialysis Transplantation, Amiens University Medical 
      Center, Amiens, France.
AD  - INSERM 1088, Jules Verne University of Picardie, Amiens, France.
FAU - Choukroun, Gabriel
AU  - Choukroun G
AD  - Department of Nephrology Dialysis Transplantation, Amiens University Medical 
      Center, Amiens, France.
AD  - INSERM 1088, Jules Verne University of Picardie, Amiens, France.
FAU - Guillaume, Nicolas
AU  - Guillaume N
AD  - Department of Histocompatibility, Amiens University Medical Center, Amiens, 
      France. guillaume.nicolas@chu-amiens.fr.
AD  - EA 4666, Jules Verne University of Picardie, Amiens, France. 
      guillaume.nicolas@chu-amiens.fr.
LA  - eng
PT  - Journal Article
DEP - 20160912
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (HLA Antigens)
RN  - 0 (Nucleic Acids)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - BK Virus/immunology/physiology
MH  - Biopsy
MH  - Female
MH  - Genotype
MH  - Graft Rejection/immunology
MH  - HLA Antigens/chemistry
MH  - Histocompatibility
MH  - Humans
MH  - *Kidney Transplantation
MH  - Killer Cells, Natural/immunology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acids/metabolism
MH  - Polyomavirus Infections/immunology/*virology
MH  - Receptors, KIR/*genetics
MH  - Renal Insufficiency/*immunology/surgery
MH  - Retrospective Studies
MH  - Tumor Virus Infections/immunology/*virology
MH  - Virus Replication
MH  - Young Adult
OTO - NOTNLM
OT  - human leukocyte antigen
OT  - BK virus
OT  - kidney transplantation
OT  - killer-cell immunoglobulin-like receptor
OT  - natural killer cell
EDAT- 2016/10/28 06:00
MHDA- 2017/08/05 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/01/28 00:00 [received]
PHST- 2016/02/25 00:00 [revised]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - 10.1111/tri.12820 [doi]
PST - ppublish
SO  - Transpl Int. 2016 Nov;29(11):1168-1175. doi: 10.1111/tri.12820. Epub 2016 Sep 12.