PMID- 27516357
OWN - NLM
STAT- MEDLINE
DCOM- 20170517
LR  - 20210109
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 27
IP  - 4
DP  - 2017 Apr
TI  - Apparent diffusion coefficient measurements in diffusion-weighted magnetic 
      resonance imaging of the anterior mediastinum: inter-observer reproducibility of 
      five different methods of region-of-interest positioning.
PG  - 1386-1394
LID - 10.1007/s00330-016-4527-8 [doi]
AB  - OBJECTIVES: To investigate inter-reader reproducibility of five different 
      region-of-interest (ROI) protocols for apparent diffusion coefficient (ADC) 
      measurements in the anterior mediastinum. METHODS: In eighty-one subjects, on ADC 
      mapping, two readers measured the ADC using five methods of ROI positioning that 
      encompassed the entire tissue (whole tissue volume [WTV], three slices 
      observer-defined [TSOD], single-slice [SS]) or the more restricted areas (one 
      small round ROI [OSR]), multiple small round ROI [MSR]). Inter-observer 
      variability was assessed with interclass correlation coefficient (ICC), 
      coefficient of variation (CoV), and Bland-Altman analysis. Nonparametric tests 
      were performed to compare the ADC between ROI methods. The measurement time was 
      recorded and compared between ROI methods. RESULTS: All methods showed excellent 
      inter-reader agreement with best and worst reproducibility in WTV and OSR, 
      respectively (ICC, 0.937/0.874; CoV, 7.3 %/16.8 %; limits of agreement, 
      +/-0.44/+/-0.77 x 10(-3) mm(2)/s). ADC values of OSR and MSR were significantly lower 
      compared to the other methods in both readers (p < 0.001). The SS and OSR methods 
      required less measurement time (14 +/- 2 s) compared to the others (p < 0.0001), 
      while the WTV method required the longest measurement time (90 +/- 56 and 77 +/- 49 s 
      for each reader) (p < 0.0001). CONCLUSIONS: All methods demonstrate excellent 
      inter-observer reproducibility with the best agreement in WTV, although it 
      requires the longest measurement time. KEY POINTS: * All ROI protocols show 
      excellent inter-observer reproducibility. * WTV measurements provide the most 
      reproducible ADC values. * ROI size and positioning influence ADC measurements in 
      the anterior mediastinum. * ADC values of OSR and MSR are significantly lower 
      than other methods. * OSR and WTV methods require the shortest and longest 
      measurement time, respectively.
FAU - Priola, Adriano Massimiliano
AU  - Priola AM
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy. adriano.priola@inwind.it.
FAU - Priola, Sandro Massimo
AU  - Priola SM
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
FAU - Parlatano, Daniela
AU  - Parlatano D
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
FAU - Gned, Dario
AU  - Gned D
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
FAU - Giraudo, Maria Teresa
AU  - Giraudo MT
AD  - Department of Mathematics "Giuseppe Peano", University of Torino, Via Carlo 
      Alberto 10, 10123, Torino, Italy.
FAU - Giardino, Roberto
AU  - Giardino R
AD  - Department of Thoracic Surgery, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
FAU - Ferrero, Bruno
AU  - Ferrero B
AD  - Department of Neurology, San Luigi Gonzaga University Hospital, Regione Gonzole 
      10, 10043, Orbassano, Torino, Italy.
FAU - Ardissone, Francesco
AU  - Ardissone F
AD  - Department of Thoracic Surgery, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
FAU - Veltri, Andrea
AU  - Veltri A
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Regione 
      Gonzole 10, 10043, Orbassano, Torino, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160811
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Mediastinal Neoplasms/*diagnostic imaging
MH  - Mediastinum/*diagnostic imaging
MH  - Middle Aged
MH  - Observer Variation
MH  - Patient Positioning/*methods
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Anterior mediastinum
OT  - Apparent diffusion coefficient
OT  - Diffusion-weighted magnetic resonance imaging
OT  - Inter-observer variability
OT  - Region of interest
EDAT- 2016/08/16 06:00
MHDA- 2017/05/18 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/05/23 00:00 [revised]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/05/18 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - 10.1007/s00330-016-4527-8 [pii]
AID - 10.1007/s00330-016-4527-8 [doi]
PST - ppublish
SO  - Eur Radiol. 2017 Apr;27(4):1386-1394. doi: 10.1007/s00330-016-4527-8. Epub 2016 
      Aug 11.