PMID- 27516392
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20211204
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 23
IP  - 1
DP  - 2017 Jan
TI  - Impact of donor-recipient genetic relationship on outcome of living donor liver 
      transplantation.
PG  - 43-49
LID - 10.1002/lt.24599 [doi]
AB  - Living donor liver transplantation (LDLT) is a valuable option for expanding the 
      donor pool, especially in localities where deceased organ harvesting is not 
      allowed. In addition, rejection rates were found to be lower in LDLT, which is 
      attributed to the fact that LDLT is usually performed between relatives. However, 
      the impact of genetic relation on the outcome of LDLT has not been studied. In 
      this study, we examined the difference in rejection rates between LDLT from 
      genetically related (GR) donors and genetically unrelated (GUR) donors. All cases 
      that underwent LDLT during the period from May 2004 until May 2014 were included 
      in the study. The study group was divided into 2 groups: LDLT from GR donors and 
      LDLT from GUR donors. A total of 308 patients were included in the study: 212 
      from GR donors and 96 from GUR donors. Human leukocyte antigen (HLA) typing was 
      not included in the workup for matching donors and recipients. GUR donors were 
      wives (36; 11.7%), sons-in-law (7; 2.3%), brothers-in-law (12; 3.9%), 
      sisters-in-law (1; 0.3%), and unrelated (38; 12.3%). The incidence of acute 
      rejection in the GR group was 17.4% and 26.3% in the GUR group (P value = 0.07). 
      However, there was a significant difference in the incidence of chronic rejection 
      (CR) between the 2 groups: 7% in GR group and 14.7% in the GUR group (P 
      value = 0.03). In terms of overall survival, there was no significant difference 
      between both groups. LDLT from the GUR donors is not associated with a higher 
      incidence of acute cellular rejection. However, CR was significantly lower when 
      grafts were procured from GR donors. HLA matching may be recommended before LDLT 
      from GUR donors. Liver Transplantation 23:43-49 2017 AASLD.
CI  - (c) 2016 by the American Association for the Study of Liver Diseases.
FAU - Ali, Mahmoud Abdelwahab
AU  - Ali MA
AUID- ORCID: 0000-0001-7958-4202
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Elshobari, Mohamed Morsi
AU  - Elshobari MM
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Salah, Tarek
AU  - Salah T
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Kandeel, Al-Refaey
AU  - Kandeel AR
AD  - Anesthesia and Intensive Care Department, Mansoura University, Mansoura City, 
      Egypt.
FAU - Sultan, Ahmad Mohammad
AU  - Sultan AM
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Elghawalby, Ahmad Nabieh
AU  - Elghawalby AN
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Shehta, Ahmed
AU  - Shehta A
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Elsayed, Usama
AU  - Elsayed U
AD  - Anesthesia and Intensive Care Department, Mansoura University, Mansoura City, 
      Egypt.
FAU - Fathy, Omar
AU  - Fathy O
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
FAU - Yassen, Amr
AU  - Yassen A
AUID- ORCID: 0000-0001-6607-7877
AD  - Anesthesia and Intensive Care Department, Mansoura University, Mansoura City, 
      Egypt.
FAU - Wahab, Mohamed Abdel
AU  - Wahab MA
AD  - Liver Transplantation Unit, Gastroenterology Surgical Center, Mansoura 
      University, Mansoura City, Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - End Stage Liver Disease/mortality/*surgery
MH  - Female
MH  - Graft Rejection/*epidemiology/genetics/immunology/prevention & control
MH  - Graft Survival/*genetics/immunology
MH  - HLA Antigens/analysis
MH  - Hepacivirus/isolation & purification
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Liver Transplantation/*methods
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Perioperative Period/mortality
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tissue and Organ Harvesting/legislation & jurisprudence/*methods
MH  - Transplant Recipients
MH  - Treatment Outcome
MH  - Unrelated Donors
EDAT- 2016/08/16 06:00
MHDA- 2017/10/17 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/04/13 00:00 [received]
PHST- 2016/07/28 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - 10.1002/lt.24599 [doi]
PST - ppublish
SO  - Liver Transpl. 2017 Jan;23(1):43-49. doi: 10.1002/lt.24599.