PMID- 27517292
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20181113
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 69
IP  - 1
DP  - 2017 Jan
TI  - Egernia stokesii (gidgee skink) MHC I positively selected sites lack concordance 
      with HLA peptide binding regions.
PG  - 49-61
LID - 10.1007/s00251-016-0947-5 [doi]
AB  - Genes of the major histocompatibility complex (MHC) play an important role in 
      vertebrate disease resistance, kin recognition and mate choice. Mammalian MHC is 
      the most widely characterised of all vertebrates, and attention is often given to 
      the peptide binding regions of the MHC because they are presumed to be under 
      stronger selection than non-peptide binding regions. For vertebrates where the 
      MHC is less well understood, researchers commonly use the amino acid positions of 
      the peptide binding regions of the human leukocyte antigen (HLA) to infer the 
      peptide binding regions within the MHC sequences of their taxon of interest. 
      However, positively selected sites within MHC have been reported to lack 
      correspondence with the HLA in fish, frogs, birds and reptiles including 
      squamates. Despite squamate diversity, the MHC has been characterised in few 
      snakes and lizards. The Egernia group of scincid lizards is appropriate for 
      investigating mechanisms generating MHC variation, as their inclusion will add a 
      new lineage (i.e. Scincidae) to studies of selection on the MHC. We aimed to 
      identify positively selected sites within the MHC of Egernia stokesii and then 
      determine if these sites corresponded with the peptide binding regions of the 
      HLA. Six positively selected sites were identified within E. stokesii MHC I, only 
      two were homologous with the HLA. E. stokesii positively selected sites 
      corresponded more closely to non-lizard than other lizard taxa. The 
      characterisation of the MHC of more intermediate taxa within the squamate order 
      is necessary to understand the evolution of the MHC across all vertebrates.
FAU - Pearson, Sarah K
AU  - Pearson SK
AD  - School of Biological Sciences, Flinders University of South Australia, Bedford 
      Park, Adelaide, 5042, Australia. sarah.pearson@flinders.edu.au.
FAU - Bull, C Michael
AU  - Bull CM
AD  - School of Biological Sciences, Flinders University of South Australia, Bedford 
      Park, Adelaide, 5042, Australia.
FAU - Gardner, Michael G
AU  - Gardner MG
AD  - School of Biological Sciences, Flinders University of South Australia, Bedford 
      Park, Adelaide, 5042, Australia.
AD  - Evolutionary Biology Unit, South Australian Museum, North Terrace, Adelaide, 
      5000, Australia.
LA  - eng
PT  - Journal Article
DEP - 20160812
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Biological Evolution
MH  - HLA Antigens/genetics/*metabolism
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Lizards/*genetics/metabolism
MH  - Peptide Fragments/genetics/*metabolism
MH  - Protein Binding
MH  - Sequence Homology, Amino Acid
OTO - NOTNLM
OT  - Egernia stokesii
OT  - MHC
OT  - Peptide binding region
OT  - Positively selected sites
OT  - Scincidae
OT  - Squamata
EDAT- 2016/08/16 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/06/05 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - 10.1007/s00251-016-0947-5 [pii]
AID - 10.1007/s00251-016-0947-5 [doi]
PST - ppublish
SO  - Immunogenetics. 2017 Jan;69(1):49-61. doi: 10.1007/s00251-016-0947-5. Epub 2016 
      Aug 12.