PMID- 27517757
OWN - NLM
STAT- MEDLINE
DCOM- 20170508
LR  - 20180415
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 151
DP  - 2016 Nov
TI  - DNA double-strand breaks in incubating female common eiders (Somateria 
      mollissima): Comparison between a low and a high polluted area.
PG  - 297-303
LID - S0013-9351(16)30318-8 [pii]
LID - 10.1016/j.envres.2016.07.031 [doi]
AB  - Alterations in the genetic material may have severe consequences for individuals 
      and populations. Hence, genotoxic effects of environmental exposure to pollutants 
      are of great concern. We assessed the impact of blood concentrations of 
      persistent organic pollutants (POPs) and mercury (Hg) on DNA double-strand break 
      (DSB) frequency, in blood cells of a high-exposed Baltic, and lower exposed 
      Arctic population of common eiders (Somateria mollissima). Furthermore, we 
      examined whether the genotoxic response was influenced by antioxidant 
      concentration (plasma total glutathione (tGSH) and total antioxidant capacity) 
      and female body mass. The DNA DSB frequency did not differ between the two 
      populations. We found significant positive relationships between Hg and DNA DSB 
      frequency in Baltic, but not in Arctic eiders. Although both p,p'-DDE and PCB 118 
      had a lesser effect than Hg, they exhibited a positive association with DNA DSB 
      frequency in Baltic eiders. Antioxidant levels were not important for the 
      genotoxic effect, suggesting alternative mechanisms other than GSH depletion for 
      the relationship between Hg and DNA DSBs. Hence, the Baltic population, which is 
      considered to be endangered and is under the influence of several environmental 
      stressors, may be more susceptible to genotoxic effects of environmental exposure 
      to Hg than the Arctic population.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Fenstad, Anette A
AU  - Fenstad AA
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Trondheim, Norway. Electronic address: anette.fenstad@gmail.com.
FAU - Bustnes, Jan O
AU  - Bustnes JO
AD  - Norwegian Institute for Nature Research (NINA), Framsenteret, Tromso, Norway.
FAU - Bingham, Christopher G
AU  - Bingham CG
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Trondheim, Norway.
FAU - Ost, Markus
AU  - Ost M
AD  - Environmental and Marine Biology, Faculty of Science and Engineering, Abo Akademy 
      University, Turku, Finland; Novia University of Applied Science (NOVIA), Coastal 
      Zone Research Team, Ekenas, Finland.
FAU - Jaatinen, Kim
AU  - Jaatinen K
AD  - Novia University of Applied Science (NOVIA), Coastal Zone Research Team, Ekenas, 
      Finland.
FAU - Moe, Borge
AU  - Moe B
AD  - NINA, Trondheim, Norway.
FAU - Hanssen, Sveinn A
AU  - Hanssen SA
AD  - Norwegian Institute for Nature Research (NINA), Framsenteret, Tromso, Norway.
FAU - Moody, A John
AU  - Moody AJ
AD  - Plymouth University, School of Biological Sciences, Plymouth, UK.
FAU - Gabrielsen, Kristin M
AU  - Gabrielsen KM
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Trondheim, Norway.
FAU - Herzke, Dorte
AU  - Herzke D
AD  - Norwegian Institute for Air Research (NILU), Framsenteret, Tromso, Norway.
FAU - Lierhagen, Syverin
AU  - Lierhagen S
AD  - NTNU, Department of Chemistry, Trondheim, Norway.
FAU - Jenssen, Bjorn M
AU  - Jenssen BM
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Trondheim, Norway.
FAU - Krokje, Ase
AU  - Krokje A
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Trondheim, Norway. Electronic address: ase.krokje@ntnu.no.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160809
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Antioxidants)
RN  - FXS1BY2PGL (Mercury)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Anseriformes/*genetics/metabolism
MH  - Antioxidants/metabolism
MH  - *DNA Breaks, Double-Stranded
MH  - Environmental Pollution/*adverse effects
MH  - Female
MH  - Glutathione/metabolism
MH  - Mercury/*toxicity
OTO - NOTNLM
OT  - Genotoxicity
OT  - Mercury
OT  - PCB
OT  - Seabirds
OT  - p,p'-DDE
EDAT- 2016/10/21 06:00
MHDA- 2017/05/10 06:00
CRDT- 2016/08/13 06:00
PHST- 2016/04/13 00:00 [received]
PHST- 2016/07/19 00:00 [revised]
PHST- 2016/07/20 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - S0013-9351(16)30318-8 [pii]
AID - 10.1016/j.envres.2016.07.031 [doi]
PST - ppublish
SO  - Environ Res. 2016 Nov;151:297-303. doi: 10.1016/j.envres.2016.07.031. Epub 2016 
      Aug 9.