PMID- 27518128
OWN - NLM
STAT- MEDLINE
DCOM- 20180228
LR  - 20191210
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Linking)
VI  - 112
IP  - 1
DP  - 2017 Jan
TI  - Is online information on ecstasy tablet content safe?
PG  - 94-100
LID - 10.1111/add.13559 [doi]
AB  - BACKGROUND AND AIMS: In recent years, the prevalence of ecstasy use has increased 
      in most European countries. Users can acquire information on ecstasy tablet 
      composition through the internet. This study compares online information from two 
      websites, Pillreports and Partyflock, to the validated Dutch Drugs Information 
      and Monitoring System (DIMS) database, and aims to measure its accuracy and 
      potential danger or value. DESIGN, SETTING, PARTICIPANTS: The drug-related 
      information posted on Pillreports.net and Partyflock.nl between 1 January 2014 
      and 31 December 2015 was investigated for accuracy and several information 
      characteristics such as picture inclusion and dose range inclusion. In total, 471 
      informatory statements on ecstasy tablet content were analysed relative to the 
      Dutch ecstasy market. MEASUREMENTS: Informatory statements on the content of 
      specific ecstasy tablets were scored as 'too high' or 'too low' if their 
      concentrations deviated > 10 mg from the entries in the DIMS database within a 
      12-week time-frame, and scored as 'dangerous' if their concentration was > 40 mg 
      too low. Unreported substances were scored as 'dangerous' if listed as an illegal 
      or dangerous substance in the DIMS database and if present in relevant 
      quantities. Also scored were the report characteristics 'picture inclusion', 
      'spread inclusion' and 'website source', which were tested for their association 
      with report safety/danger. FINDINGS: On average, reports on ecstasy tablets from 
      Pillreports and Partyflock show concentrations which are 10.6 mg too high [95% 
      confidence interval (CI) = 6.7-14.4]. Qualitatively, 39.7% of the reports scored 
      as 'too high' (95% CI = 35.2-44.4), 17.6% scored as 'too low' (95% 
      CI = 14.0-21.2) and 15.5% had 'unreported substances' (95% CI = 12.3-18.9), 
      resulting overall in 15.3% of the reports being scored as 'dangerous' (95% 
      CI = 11.9-18.5). The report characteristic 'spread inclusion' associated 
      inversely with report danger [Exp(b) = 0.511, 95% CI = 0.307-0.850, P = 0.01]. 
      CONCLUSION: Information from the popular Pillreports and Partyflock websites 
      tends to overestimate 3,4-methylenedioxymethamphetamine (MDMA) concentrations in 
      ecstasy tablets. In addition, 15.3% of the reports omit the relevant 
      concentration spread, fail to report additional illegal or dangerous substances 
      contained in the tablets or underestimate MDMA concentration by > 40 mg.
CI  - (c) 2016 Society for the Study of Addiction.
FAU - Vrolijk, Ruben Q
AU  - Vrolijk RQ
AD  - Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, 
      the Netherlands.
FAU - Brunt, Tibor M
AU  - Brunt TM
AD  - Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, 
      the Netherlands.
AD  - Academic Medical Centre, Department of Psychiatry, Amsterdam, the Netherlands.
FAU - Vreeker, Annabel
AU  - Vreeker A
AD  - Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, 
      the Netherlands.
AD  - Department of Psychology, Section Health, Medical and Neuropsychology, Leiden 
      University, the Netherlands.
FAU - Niesink, Raymond J M
AU  - Niesink RJ
AD  - Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, 
      the Netherlands.
AD  - Faculty of Management, Science and Technology, School of Science, Open University 
      of the Netherlands, Heerlen, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160921
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - Addiction. 2017 Jan;112(1):101-102. PMID: 27936508
MH  - Hallucinogens/*analysis
MH  - Humans
MH  - Illicit Drugs/*analysis
MH  - *Internet
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Netherlands
OTO - NOTNLM
OT  - DIMS
OT  - Ecstasy
OT  - MDMA
OT  - internet
OT  - online information
OT  - pill reports
EDAT- 2016/08/16 06:00
MHDA- 2018/03/01 06:00
CRDT- 2016/08/13 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2015/12/15 00:00 [revised]
PHST- 2016/08/08 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2018/03/01 06:00 [medline]
PHST- 2016/08/13 06:00 [entrez]
AID - 10.1111/add.13559 [doi]
PST - ppublish
SO  - Addiction. 2017 Jan;112(1):94-100. doi: 10.1111/add.13559. Epub 2016 Sep 21.