PMID- 27520567
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20220410
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 274
IP  - 1
DP  - 2017 Jan
TI  - The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, 
      and red cell distribution width predict prognosis in patients with laryngeal 
      carcinoma.
PG  - 535-542
LID - 10.1007/s00405-016-4250-8 [doi]
AB  - The aim of this study was to identify the potential prognostic roles of the 
      preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio 
      (PLR), and red cell distribution width (RDW) in patients with laryngeal squamous 
      cell carcinoma (LSCC). 81 patients who underwent surgery for the larynx carcinoma 
      were enrolled in the study. NLR, PLR and RDW were used as outcome measures. Local 
      recurrence was detected in 30 (37.0 %) patients and neck lymph node metastasis 
      was detected 6 (7.4 %) patients during follow-up period. Mortality was seen in 7 
      (8.6 %) patients. The mean PLR in the T1 and T2 stage tumors were significantly 
      lower than the T4 stage. The mean RDW and PLR were significantly higher in the 
      exitus group than the survivor group. The mean NLR in the patients with local 
      recurrence was significantly higher than the non-recurrent patients. 
      Progression-free survival (PFS) was lower in patients with high NLR. When 
      analyzed by the Cox regression analysis of factors affecting the local 
      recurrence, NLR was found to significantly affect the recurrence. According to 
      ROC analysis for mortality, NLR was not found to be a prognostic factor, although 
      the PLR and RDW were significant prognostic factors. According to Cox regression 
      analysis, a high PLR increases mortality 4.2 times and a high RDW 4.6 times. 
      Although in univariate analysis MCV, RDW and tumor grade were predictors of 
      mortality, RDW and tumor grade independent predictors were found. Further studies 
      involving large patient groups are required.
FAU - Kara, Medine
AU  - Kara M
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart 
      University, Canakkale, Turkey. medinekara@gmail.com.
FAU - Uysal, Sema
AU  - Uysal S
AD  - Department of Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart 
      University, Canakkale, Turkey.
FAU - Altinisik, Ugur
AU  - Altinisik U
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Canakkale 
      Onsekiz Mart University, Canakkale, Turkey.
FAU - Cevizci, Sibel
AU  - Cevizci S
AD  - Department of Public Health, Faculty of Medicine, Canakkale Onsekiz Mart 
      University, Canakkale, Turkey.
FAU - Guclu, Oguz
AU  - Guclu O
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart 
      University, Canakkale, Turkey.
FAU - Derekoy, Fevzi Sefa
AU  - Derekoy FS
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart 
      University, Canakkale, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160812
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*blood/pathology/surgery
MH  - Disease-Free Survival
MH  - *Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/pathology/surgery
MH  - *Leukocyte Count
MH  - Lymphatic Metastasis
MH  - Lymphocytes/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/pathology
MH  - Neutrophils/*pathology
MH  - *Platelet Count
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Larynx carcinoma
OT  - Neutrophil-to-lymphocyte ratio
OT  - Platelet-to-lymphocyte ratio
OT  - Prognosis
OT  - Red cell distribution width
EDAT- 2016/08/16 06:00
MHDA- 2017/02/23 06:00
CRDT- 2016/08/14 06:00
PHST- 2016/07/20 00:00 [received]
PHST- 2016/08/05 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
PHST- 2016/08/14 06:00 [entrez]
AID - 10.1007/s00405-016-4250-8 [pii]
AID - 10.1007/s00405-016-4250-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2017 Jan;274(1):535-542. doi: 
      10.1007/s00405-016-4250-8. Epub 2016 Aug 12.