PMID- 27521295
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20181202
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 218
DP  - 2016 Nov
TI  - Country-specific chemical signatures of persistent organic pollutants (POPs) in 
      breast milk of French, Danish and Finnish women.
PG  - 728-738
LID - S0269-7491(16)30644-3 [pii]
LID - 10.1016/j.envpol.2016.07.069 [doi]
AB  - The present study compares concentrations and chemical profiles of an extended 
      range of persistent organic pollutants (dioxins, polychlorobiphenyls, brominated 
      flame retardants and organochlorine pesticides) in breast milk samples from 
      French (n = 96), Danish (n = 438) and Finnish (n = 22) women. Median exposure 
      levels observed in French women (WHO-TEQ(2005) PCDD/F = 6.1 pg/g l.w., 
      WHO-TEQ(2005) dl-PCB = 4.3 pg/g l.w., sum of 6 ndl-PCB = 85.2 ng/g l.w., sum of 7 
      i-PBDE = 1.5 ng/g l.w.) appeared overall lower than in Danish and Finnish women 
      for all examined POPs, except for alpha-HBCD (2-fold higher level at 0.6 ng/g l.w.). 
      Furthermore, the observed exposure levels of dioxins and PCBs were higher in 
      Danish women (WHO-TEQ(2005) PCDD/F = 13.2 pg/g l.w., WHO-TEQ(2005) 
      dl-PCB = 6.6 pg/g l.w., sum of 6 ndl-PCB = 162.8 ng/g l.w.) compared to Finnish 
      women (WHO-TEQ(2005) PCDD/F = 9.0 pg/g l.w., WHO-TEQ(2005) dl-PCB = 4.6 pg/g 
      l.w., sum of 6 ndl-PCB = 104.0 ng/g l.w.), whereas the concentrations of PBDEs 
      were similar for Danish and Finnish women (sum of 7 i-PBDE = 4.9 and 5.2 ng/g 
      l.w. respectively). The organochlorine (OC) pesticide contamination profile, 
      determined in a subset of French samples, was dominated by p,p'-DDE (56.6%), 
      followed by beta-HCH (14.2%), HCB (9.7%) and dieldrin (5.2%), while other compounds 
      were only minor contributors (<5%). The three countries appeared to be 
      discriminated by the observed contamination patterns of the PCDD/F versus PCB, 
      and the 1,2,3,6,7,8-HxCDD versus 1,2,3,4,7,8-HxCDD ratios, in addition to the 
      relative contributions of specific congeners to the contamination profile (PCBs 
      #118 and #156, PBDEs #28, #47, #99 and #153). In conclusion, unique chemical 
      signatures were observed for each country on the basis of some POP congeners. 
      Future biomonitoring studies will need to consider the high variability of 
      individual exposure profiles in relation to multiple exposure sources but also 
      physiological and metabolic differences.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Antignac, J P
AU  - Antignac JP
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France; INRA, Nantes, F-44307, 
      France. Electronic address: laberca@oniris-nantes.fr.
FAU - Main, K M
AU  - Main KM
AD  - Department of Growth and Reproduction, Faculty of Medical and Health Sciences, 
      University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark.
FAU - Virtanen, H E
AU  - Virtanen HE
AD  - Department of Physiology, Institute of Biomedicine, University of Turku, Finland.
FAU - Boquien, C Y
AU  - Boquien CY
AD  - UMR 1280 PHAN Physiologie des Adaptations Nutritionnelles, Nantes, France; INRA, 
      Nantes, F-44307, France; CRNH Ouest, 44093, Nantes, France.
FAU - Marchand, P
AU  - Marchand P
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Venisseau, A
AU  - Venisseau A
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Guiffard, I
AU  - Guiffard I
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Bichon, E
AU  - Bichon E
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Wohlfahrt-Veje, C
AU  - Wohlfahrt-Veje C
AD  - Department of Growth and Reproduction, Faculty of Medical and Health Sciences, 
      University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark.
FAU - Legrand, A
AU  - Legrand A
AD  - Centre d'investigation Clinique mere-enfant, Service de Neonatologie et de 
      Reanimation Pediatrique, Hopital Mere-Enfant, CHU de Nantes, France.
FAU - Boscher, C
AU  - Boscher C
AD  - Centre d'investigation Clinique mere-enfant, Service de Neonatologie et de 
      Reanimation Pediatrique, Hopital Mere-Enfant, CHU de Nantes, France.
FAU - Skakkebaek, Niels E
AU  - Skakkebaek NE
AD  - Department of Growth and Reproduction, Faculty of Medical and Health Sciences, 
      University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark.
FAU - Toppari, J
AU  - Toppari J
AD  - Department of Physiology, Institute of Biomedicine, University of Turku, Finland; 
      Department of Pediatrics, Turku University Hospital, Turku, Finland.
FAU - Le Bizec, B
AU  - Le Bizec B
AD  - LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
LA  - eng
PT  - Journal Article
DEP - 20160809
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Denmark
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*chemistry/metabolism
MH  - Female
MH  - Finland
MH  - Flame Retardants/*analysis
MH  - France
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis
MH  - Milk, Human/*chemistry
MH  - Pesticides/*chemistry/metabolism
MH  - Polychlorinated Biphenyls/*chemistry
OTO - NOTNLM
OT  - Breast milk
OT  - Dioxin
OT  - HBCD
OT  - PBDE
OT  - PCB
OT  - Perinatal exposure
OT  - Persistent organic pollutants
EDAT- 2016/08/16 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/08/14 06:00
PHST- 2016/03/27 00:00 [received]
PHST- 2016/07/28 00:00 [revised]
PHST- 2016/07/29 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/08/14 06:00 [entrez]
AID - S0269-7491(16)30644-3 [pii]
AID - 10.1016/j.envpol.2016.07.069 [doi]
PST - ppublish
SO  - Environ Pollut. 2016 Nov;218:728-738. doi: 10.1016/j.envpol.2016.07.069. Epub 
      2016 Aug 9.