PMID- 27521747
OWN - NLM
STAT- MEDLINE
DCOM- 20170216
LR  - 20170904
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 147
DP  - 2016 Nov 1
TI  - Ibuprofen-loaded porous microspheres suppressed the progression of monosodium 
      iodoacetate-induced osteoarthritis in a rat model.
PG  - 265-273
LID - S0927-7765(16)30552-5 [pii]
LID - 10.1016/j.colsurfb.2016.07.050 [doi]
AB  - The objectives of this study were (1) to fabricate ibuprofen-loaded porous 
      microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects 
      of the microspheres using LPS-induced inflammation in cultured synoviocytes, and 
      (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of 
      monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model. A 
      dose-dependent in vitro anti-inflammatory effect on pro-inflammatory cytokine 
      markers (matrix metallopeptidase-3 (MMP-3), matrix metallopeptidase-13 (MMP-13), 
      cyclooxygenase-2 (COX-2), a disintegrin and metalloproteinase with thrombospondin 
      motifs-5 (ADAMTS-5)), interleukin-6 (IL-6), and tumor necrosis factor (TNF-alpha) was 
      observed by confirming with real-time PCR analyses. In vivo, treatment with 
      IBU/PMSs reduced MIA-stimulated mRNA expression of MMP-3, MMP-13, COX-2, 
      ADAMTS-5, IL-6, and TNF-alpha in rat synoviocytes. In addition, we demonstrated that 
      intra-articular IBU/PMSs suppressed the progression of MIA-induced OA in the rat 
      model via anti-inflammatory mechanisms. In conclusion, IBU/PMSs are a promising 
      therapeutic material to control the pain and progression of OA.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Park, Jang Won
AU  - Park JW
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea.
FAU - Yun, Young-Pil
AU  - Yun YP
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea.
FAU - Park, Kyeongsoon
AU  - Park K
AD  - Division of Biological Imaging, Chuncheon Center, Korea Basic Science Institute, 
      192-1 Hyoja 2-dong, Chuncheon, Gangwon-do 200-701 Republic of Korea.
FAU - Lee, Jae Yong
AU  - Lee JY
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea; Department of Biomedical Science, College of Medicine, Korea 
      University, Anam-dong, Seongbuk-gu, 136-701 Republic of Korea.
FAU - Kim, Hak-Jun
AU  - Kim HJ
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea.
FAU - Kim, Sung Eun
AU  - Kim SE
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea. Electronic address: sekim10@korea.ac.kr.
FAU - Song, Hae-Ryong
AU  - Song HR
AD  - Department of Orthopedic Surgery and Rare Diseases Institute, Korea University 
      Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 152-703 Republic 
      of Korea. Electronic address: songhae@korea.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20160728
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 3.4.24.- (MMP13 protein, human)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - WF5188V710 (Iodoacetic Acid)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Arthritis, Experimental/chemically induced/pathology/*prevention & control
MH  - Cell Proliferation/*drug effects
MH  - Chondrocytes/cytology/drug effects/metabolism
MH  - Cyclooxygenase 2/genetics
MH  - Cytokines/metabolism
MH  - Enzyme Inhibitors/toxicity
MH  - Ibuprofen/*pharmacology
MH  - Inflammation Mediators/metabolism
MH  - Iodoacetic Acid/*toxicity
MH  - Male
MH  - Matrix Metalloproteinase 13/genetics
MH  - *Microspheres
MH  - Osteoarthritis/chemically induced/pathology/*prevention & control
MH  - Rats
MH  - Real-Time Polymerase Chain Reaction
MH  - Tumor Necrosis Factor-alpha/genetics
OTO - NOTNLM
OT  - Anti-inflammatory effect
OT  - Ibuprofen
OT  - Osteoarthritis
OT  - PLGA
OT  - Porous microspheres
EDAT- 2016/08/16 06:00
MHDA- 2017/02/17 06:00
CRDT- 2016/08/14 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/06/17 00:00 [revised]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/08/14 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/02/17 06:00 [medline]
AID - S0927-7765(16)30552-5 [pii]
AID - 10.1016/j.colsurfb.2016.07.050 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2016 Nov 1;147:265-273. doi: 
      10.1016/j.colsurfb.2016.07.050. Epub 2016 Jul 28.