PMID- 27522214
OWN - NLM
STAT- MEDLINE
DCOM- 20171031
LR  - 20181202
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Print)
IS  - 0962-9343 (Linking)
VI  - 25
IP  - 11
DP  - 2016 Nov
TI  - Measuring health-related quality of life in patients with conservatively managed 
      stage 5 chronic kidney disease: limitations of the Medical Outcomes Study Short 
      Form 36: SF-36.
PG  - 2799-2809
AB  - PURPOSE: Chronic kidney disease (CKD) negatively affects health-related quality 
      of life (HRQoL), which is often measured using the Medical Outcomes Study Short 
      Form 36 (SF-36) questionnaire. However, the adequacy of SF-36 in this population 
      has not been reported. We aimed to determine floor and ceiling effects and 
      responsiveness to change of SF-36 in patients with conservatively managed stage 5 
      CKD. METHODS: SF-36 data were collected prospectively. Floor and ceiling effects 
      were estimated for each SF-36 scale and summary measure based on raw scores. The 
      minimal clinically important difference (MCID) was estimated using a combination 
      of anchor-based and distribution-based methods. Responsiveness to change was 
      assessed by comparing MCID for each scale and summary measure to its smallest 
      detectable change. RESULTS: SF-36 data were available for 73 of the 74 study 
      participants. Using baseline data, floor and/or ceiling effects were detected for 
      3 of the 8 SF-36 scales. The anchor-based estimation of MCID based on differences 
      in baseline functional status yielded the most reliable results. For the physical 
      component summary, MCID was estimated at 5.7 points. Whilst the two SF-36 summary 
      measures were responsive to change and free of floor and/or ceiling effects, six 
      of the eight scales were not. CONCLUSIONS: This small study of patients with 
      conservatively managed stage 5 CKD found that only the summary measures of SF-36 
      and 2 of its 8 scales can be used to assess changes in HRQoL over time. These 
      findings suggest that in this population, alternative HRQoL assessment tools 
      should be considered for future studies.
FAU - Erez, Gilli
AU  - Erez G
AUID- ORCID: 0000-0001-8673-4299
AD  - Palliative Care Team, Northwick Park Hospital, London North West Healthcare NHS 
      Trust, Watford Road, Harrow, London, HA1 3UJ, UK.
FAU - Selman, Lucy
AU  - Selman L
AD  - Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders 
      Institute, King's College London, London, UK.
FAU - Murtagh, Fliss E M
AU  - Murtagh FE
AD  - Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders 
      Institute, King's College London, London, UK. fliss.murtagh@kcl.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20160813
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Aged, 80 and over
MH  - *Disability Evaluation
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Quality of Life/*psychology
MH  - Renal Insufficiency, Chronic/*psychology
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
PMC - PMC5065617
OTO - NOTNLM
OT  - Chronic kidney diseases
OT  - Longitudinal studies
OT  - Quality of life
OT  - Short Form 36 Health Survey
EDAT- 2016/08/16 06:00
MHDA- 2017/11/01 06:00
PMCR- 2016/08/13
CRDT- 2016/08/15 06:00
PHST- 2016/05/03 00:00 [accepted]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/11/01 06:00 [medline]
PHST- 2016/08/15 06:00 [entrez]
PHST- 2016/08/13 00:00 [pmc-release]
AID - 10.1007/s11136-016-1313-7 [pii]
AID - 1313 [pii]
AID - 10.1007/s11136-016-1313-7 [doi]
PST - ppublish
SO  - Qual Life Res. 2016 Nov;25(11):2799-2809. doi: 10.1007/s11136-016-1313-7. Epub 
      2016 Aug 13.