PMID- 27522736
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20191113
IS  - 0250-636X (Print)
IS  - 0250-636X (Linking)
VI  - 36
IP  - 3
DP  - 2015 Jul-Sep
TI  - HLA - DQ genotyping in celiac disease in western India.
PG  - 174-8
AB  - BACKGROUND AND AIMS: Very few human leukocyte antigen (HLA) studies have been 
      carried out in celiac disease patients in India. The aim was to study the HLA DQ 
      antigens in diagnosed celiac disease patients. METHODS: The cross sectional study 
      analysed non-consecutive 34 celiac patients diagnosed as per modified ESPGHAN 
      criteria at tertiary centre and compared with 25 controls. The HLA-DQ typing was 
      carried out using Histo Spot SSO HLA DQ celiac disease kit by tissue typing 
      department. RESULTS: Out of 34 celiac disease patients (26 females, age +/- SD 
      38.79 +/- 15.84 years), 59% presented with typical diarrheal disease. Anemia (76%) 
      was most common extra intestinal manifestation followed by bone pain (53%), 
      neurological (12%) and infertility (3%). All 34 patients were IgA antiendomysial 
      antibody positive out of which 32 patients (94%) were HLA-DQ positive (31 
      patients were HLA-DQ 2 and 1 was HLA-DQ 8 positive).Among HLA positive patients 
      13, 9 and 10 patients had modified Marsh stage 1, 2 and 3 respectively. HLA DQ 2 
      and DQ8 positivity among celiac patients (94%) was statistically significant as 
      compared to controls (12%) (P< 0.0001). HLA DQ 2.5 (DQA1*0501 :DQB1*0201 
      haplotype) and DQ 2 (DQB1*02) haplotypes were common accounting for 70% of 
      patients followed by DQ X.5, DQ8 and DQ 2.2. CONCLUSION: Celiac disease in Indian 
      patients is predominantly associated with HLA DQ 2 and DQ 8 genotype and has high 
      positive predictive value for diagnosis when combined with serology in 
      symptomatic patients.
FAU - Amarapurkar, Deepak N
AU  - Amarapurkar DN
FAU - Somani, Vaibhav S
AU  - Somani VS
FAU - Shah, Apurva S
AU  - Shah AS
FAU - Kankonkar, Sharada R
AU  - Kankonkar SR
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Gastroenterol
JT  - Tropical gastroenterology : official journal of the Digestive Diseases Foundation
JID - 8107122
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Celiac Disease/*genetics
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - India
MH  - Male
MH  - Retrospective Studies
EDAT- 2016/08/16 06:00
MHDA- 2016/09/02 06:00
CRDT- 2016/08/16 06:00
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
AID - 10.7869/tg.279 [doi]
PST - ppublish
SO  - Trop Gastroenterol. 2015 Jul-Sep;36(3):174-8. doi: 10.7869/tg.279.