PMID- 27523919
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20220317
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 83
DP  - 2016 Oct
TI  - Effect of creatine supplementation and drop-set resistance training in untrained 
      aging adults.
PG  - 112-9
LID - S0531-5565(16)30256-X [pii]
LID - 10.1016/j.exger.2016.08.005 [doi]
AB  - OBJECTIVE: To investigate the effects of creatine supplementation and drop-set 
      resistance training in untrained aging adults. Participants were randomized to 
      one of two groups: Creatine (CR: n=14, 7 females, 7 males; 58.0+/-3.0yrs, 
      0.1g/kg/day of creatine+0.1g/kg/day of maltodextrin) or Placebo (PLA: n=17, 7 
      females, 10 males; age: 57.6+/-5.0yrs, 0.2g/kg/day of maltodextrin) during 12weeks 
      of drop-set resistance training (3days/week; 2 sets of leg press, chest press, 
      hack squat and lat pull-down exercises performed to muscle fatigue at 80% 
      baseline 1-repetition maximum [1-RM] immediately followed by repetitions to 
      muscle fatigue at 30% baseline 1-RM). METHODS: Prior to and following training 
      and supplementation, assessments were made for body composition, muscle strength, 
      muscle endurance, tasks of functionality, muscle protein catabolism and diet. 
      RESULTS: Drop-set resistance training improved muscle mass, muscle strength, 
      muscle endurance and tasks of functionality (p<0.05). The addition of creatine to 
      drop-set resistance training significantly increased body mass (p=0.002) and 
      muscle mass (p=0.007) compared to placebo. Males on creatine increased muscle 
      strength (lat pull-down only) to a greater extent than females on creatine 
      (p=0.005). Creatine enabled males to resistance train at a greater capacity over 
      time compared to males on placebo (p=0.049) and females on creatine (p=0.012). 
      Males on creatine (p=0.019) and females on placebo (p=0.014) decreased 3-MH 
      compared to females on creatine. CONCLUSIONS: The addition of creatine to 
      drop-set resistance training augments the gains in muscle mass from resistance 
      training alone. Creatine is more effective in untrained aging males compared to 
      untrained aging females.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Johannsmeyer, Sarah
AU  - Johannsmeyer S
AD  - Faculty of Kinesiology and Health Studies, University of Regina, Canada.
FAU - Candow, Darren G
AU  - Candow DG
AD  - Faculty of Kinesiology and Health Studies, University of Regina, Canada. 
      Electronic address: Darren.Candow@uregina.ca.
FAU - Brahms, C Markus
AU  - Brahms CM
AD  - Faculty of Kinesiology and Health Studies, University of Regina, Canada.
FAU - Michel, Deborah
AU  - Michel D
AD  - College of Pharmacy and Nutrition, University of Saskatchewan, Canada.
FAU - Zello, Gordon A
AU  - Zello GA
AD  - College of Pharmacy and Nutrition, University of Saskatchewan, Canada.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160811
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - *Aging
MH  - Body Composition
MH  - Canada
MH  - Creatine/*administration & dosage
MH  - Diet
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Fatigue
MH  - Muscle Strength/*drug effects
MH  - Muscle, Skeletal/*drug effects
MH  - Organ Size
MH  - Physical Endurance/drug effects
MH  - Resistance Training/*methods
MH  - Sex Factors
OTO - NOTNLM
OT  - Endurance
OT  - Muscle mass
OT  - Muscle protein catabolism
OT  - Sarcopenia
OT  - Strength
EDAT- 2016/08/16 06:00
MHDA- 2017/10/17 06:00
CRDT- 2016/08/16 06:00
PHST- 2016/06/15 00:00 [received]
PHST- 2016/08/04 00:00 [revised]
PHST- 2016/08/10 00:00 [accepted]
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
AID - S0531-5565(16)30256-X [pii]
AID - 10.1016/j.exger.2016.08.005 [doi]
PST - ppublish
SO  - Exp Gerontol. 2016 Oct;83:112-9. doi: 10.1016/j.exger.2016.08.005. Epub 2016 Aug 
      11.