PMID- 27525026
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160815
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - Assessment of the Therapeutic Effect of Total Glucosides of Peony for Juvenile 
      Idiopathic Arthritis: A Systematic Review and Meta-Analysis.
PG  - 8292486
LID - 10.1155/2016/8292486 [doi]
LID - 8292486
AB  - Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in 
      children; some clinical trials have reported the effects of total glucosides of 
      peony (TGP) in the treatment of JIA. However, no systematic review has yet been 
      conducted. In this study, we assessed the efficacy and safety in patients with 
      JIA enrolled in randomized controlled trials (RCTs) of TGP. We extracted data for 
      studies searched from 8 electronic databases that were searched and also 
      evaluated the methodological quality of the included studies. We assessed the 
      following outcome measures: overall response rate, pain, tender joint count 
      (TJC), swollen joint count (SJC), duration of morning stiffness (DMS), grip 
      strength (GS), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), 
      C-reactive protein (CRP), and adverse effects (AEs) in short term (4-8 weeks), 
      intermediate term (9-26 weeks), and long term (>26 weeks). The final analysis 
      showed that TGP acted as a unique nonbiologic disease-modifying antirheumatic 
      drug (nonbiologic DMARD), and its therapeutic effects were safe and efficacious 
      for the treatment of JIA with few AEs. However, more high-quality RCTs are needed 
      to confirm these therapeutic effects.
FAU - Cai, Yongsong
AU  - Cai Y
AD  - Department of Orthopaedics, The First Affiliated Hospital, Xi'an Jiaotong 
      University Health Science Center, Xi'an 710061, China.
FAU - Yuan, Qiling
AU  - Yuan Q
AD  - Department of Orthopaedics, The First Affiliated Hospital, Xi'an Jiaotong 
      University Health Science Center, Xi'an 710061, China.
FAU - Xu, Ke
AU  - Xu K
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
FAU - Zhu, Jialin
AU  - Zhu J
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
FAU - Li, Yuanbo
AU  - Li Y
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
FAU - Wu, Xiaoqing
AU  - Wu X
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
FAU - Yang, Le
AU  - Yang L
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
FAU - Qiu, Yusheng
AU  - Qiu Y
AUID- ORCID: 0000-0001-5303-4800
AD  - Department of Orthopaedics, The First Affiliated Hospital, Xi'an Jiaotong 
      University Health Science Center, Xi'an 710061, China.
FAU - Xu, Peng
AU  - Xu P
AUID- ORCID: 0000-0003-2487-9163
AD  - Department of Joint Surgery, Xi'an Hong Hui Hospital, Xi'an Jiaotong University 
      Health Science Center, Xi'an 710054, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160725
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4976154
EDAT- 2016/08/16 06:00
MHDA- 2016/08/16 06:01
PMCR- 2016/07/25
CRDT- 2016/08/16 06:00
PHST- 2016/01/26 00:00 [received]
PHST- 2016/05/29 00:00 [revised]
PHST- 2016/05/31 00:00 [accepted]
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2016/08/16 06:01 [medline]
PHST- 2016/07/25 00:00 [pmc-release]
AID - 10.1155/2016/8292486 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:8292486. doi: 10.1155/2016/8292486. 
      Epub 2016 Jul 25.