PMID- 27525587
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20200930
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Linking)
VI  - 16
IP  - 9
DP  - 2016 Sep 14
TI  - Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer 
      Photodynamic Immunotherapy.
PG  - 5503-13
LID - 10.1021/acs.nanolett.6b01994 [doi]
AB  - Photodynamic therapy (PDT) has emerged as a promising clinical modality for 
      cancer therapy due to its ability to initiate an antitumor immune response. 
      However, PDT-mediated cancer immunotherapy is severely impaired by tumor-cell 
      immunosuppression of host T cell antitumor activity through the programmed cell 
      death 1 ligand (PD-L1) and programmed cell death receptor 1 (PD-1) (PD-L1-PD-1) 
      immune checkpoint pathway. Here, we demonstrate that PDT-mediated cancer 
      immunotherapy can be augmented by PD-L1 knockdown (KD) in tumor cells. We 
      rationally designed a versatile micelleplex by integrating an acid-activatable 
      cationic micelle, photosensitizer (PS), and small interfering RNA (siRNA). The 
      micelleplex was inert at physiological pH conditions and activated only upon 
      internalization in the acidic endocytic vesicles of tumor cells for fluorescence 
      imaging and PDT. Compared to PDT alone, the combination of PDT and PD-L1 KD 
      showed significantly enhanced efficacy for inhibiting tumor growth and distant 
      metastasis in a B16-F10 melanoma xenograft tumor model. These results suggest 
      that acid-activatable micelleplexes utilizing PDT-induced cancer immunotherapy 
      are more effective when combined with siRNA-mediated PD-L1 blockade. This study 
      could provide a general strategy for enhancing the therapy efficacy of 
      photodynamic cancer therapy.
FAU - Wang, Dangge
AU  - Wang D
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
AD  - University of Chinese Academy of Sciences , Beijing 100049, China.
FAU - Wang, Tingting
AU  - Wang T
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
AD  - University of Chinese Academy of Sciences , Beijing 100049, China.
FAU - Liu, Jianping
AU  - Liu J
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Yu, Haijun
AU  - Yu H
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Jiao, Shi
AU  - Jiao S
AD  - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological 
      Sciences, Chinese Academy of Sciences , Shanghai 200031, China.
FAU - Feng, Bing
AU  - Feng B
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
AD  - University of Chinese Academy of Sciences , Beijing 100049, China.
FAU - Zhou, Fangyuan
AU  - Zhou F
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Fu, Yuanlei
AU  - Fu Y
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Yin, Qi
AU  - Yin Q
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Zhang, Pengcheng
AU  - Zhang P
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Zhang, Zhiwen
AU  - Zhang Z
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
FAU - Zhou, Zhaocai
AU  - Zhou Z
AD  - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological 
      Sciences, Chinese Academy of Sciences , Shanghai 200031, China.
FAU - Li, Yaping
AU  - Li Y
AD  - State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai 
      Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160817
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - *Immunotherapy
MH  - Melanoma, Experimental/*drug therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Photochemotherapy
MH  - Photosensitizing Agents
MH  - Programmed Cell Death 1 Receptor
MH  - T-Lymphocytes
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Micelleplexes
OT  - RNA interference
OT  - acid-activatable
OT  - cancer immunotherapy
OT  - photodynamic therapy
EDAT- 2016/08/16 06:00
MHDA- 2018/10/03 06:00
CRDT- 2016/08/16 06:00
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
AID - 10.1021/acs.nanolett.6b01994 [doi]
PST - ppublish
SO  - Nano Lett. 2016 Sep 14;16(9):5503-13. doi: 10.1021/acs.nanolett.6b01994. Epub 
      2016 Aug 17.