PMID- 27525837
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20210816
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 3
DP  - 2016 Jul 15
TI  - Validation of associations between ESR1 variants and breast cancer risk in 
      Chinese cohorts.
LID - 10.4238/gmr.15036683 [doi]
AB  - Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and 
      common genetic variants in the corresponding gene locus have been associated with 
      breast cancer risk in different populations. Here, we analyzed estrogen receptor 
      1 (ESR1) associations in two hospital-based studies of patients from the south of 
      China. Three single-nucleotide polymorphisms (SNPs; rs3757318, rs2046210, and 
      rs3734805) in ESR1 were selected from previous genome-wide association study 
      results and were genotyped using the Sequenom MassARRAY(R) iPLEX System in 845 
      breast cancer patients and 882 healthy controls. Association analysis based on 
      unconditional logistic regression was carried out to determine the odds ratio 
      (OR) and 95% confidence interval (95%CI) for each SNP. Stratified analyses 
      according to the status of ER and progesterone receptor (PR) were also performed. 
      Of the three SNPs, rs3757318 did not pass the Hardy-Weinberg equilibrium test and 
      was excluded from the subsequent analysis. The other two SNPs (rs2046210 and 
      rs3734805) were strongly associated with susceptibility to breast cancer. Allele 
      T of rs2046210 and allele C of rs3734805 were risk alleles and the adjusted ORs 
      were 1.348 (95%CI = 1.172-1.550, P = 0.0001) and 1.319 (95%CI = 1.144-1.522, P = 
      0.0001), respectively. Furthermore, the risk allele of rs2046210 gave negative 
      results for ER and PR expression in an immunohistochemical test, with ORs of 
      0.602 (95%CI = 0.384-0.944, P = 0.027) and 0.532 (95%CI = 0.338-0.837, P = 
      0.006), respectively. Our study further supports associations between rs2046210 
      and rs3734805 and breast cancer risk in Chinese women.
FAU - Li, X
AU  - Li X
AD  - Clinical Laboratory of Nanfang Hospital, Southern Medical University, Guangzhou, 
      China.
FAU - Yao, G Y
AU  - Yao GY
AD  - Breast Cancer Center, Nanfang Hospital, Southern Medical University, Guangzhou, 
      China.
FAU - Li, F X
AU  - Li FX
AD  - School of Biotechnology, Southern Medical University, Guangzhou, China.
FAU - Qiu, Y R
AU  - Qiu YR
AD  - Clinical Laboratory of Nanfang Hospital, Southern Medical University, Guangzhou, 
      China.
FAU - Yang, X X
AU  - Yang XX
AD  - School of Biotechnology, Southern Medical University, Guangzhou, China 
      yxxzb@sohu.com.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*genetics
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Humans
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
COIS- The authors declare no conflict of interest.
EDAT- 2016/08/16 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/08/16 06:00
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - gmr6683 [pii]
AID - 10.4238/gmr.15036683 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Jul 15;15(3). doi: 10.4238/gmr.15036683.