PMID- 27525870
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 3
DP  - 2016 Jul 25
TI  - Association between the interleukin 4 gene -590C>T promoter polymorphism and 
      asthma in Xinjiang Uighur children.
LID - 10.4238/gmr.15038363 [doi]
AB  - We investigated the association between the interleukin 4 gene (IL-4) -590C>T 
      polymorphism and forced expiratory volume in one second (FEV1) values, 
      immunoglobulin E (IgE) levels, and susceptibility to asthma in Uighur children. 
      IL-4 -590C>T frequencies were analyzed in 38 bronchial asthmatic patients and 35 
      non-asthmatic controls. Polymerase chain reaction and direct sequencing were 
      applied to determine the residue at position -590 of IL-4. Total serum IgE levels 
      were detected by enzyme-linked immunosorbent assay, while lung function was 
      examined by professionals. There were significant differences in the distribution 
      of IL-4 -590C>T genotypes and alleles between patient and control groups 
      (genotypes: chi-square = 11.476, P < 0.05; alleles: chi-square = 14.572, P < 
      0.05). Frequencies of CC, CT, and TT genotypes were 21, 29, and 50% among 
      patients, and 49, 37, and 14% among controls, respectively, indicating that the T 
      allele was significantly more frequent in the asthma group than in the control 
      group. Total serum IgE levels were significantly higher (P < 0.05) and FEV1 
      values were significantly lower (F = 13.294, P < 0.05) in patients than in 
      control subjects of the same genotype. In conclusion, the IL-4 -590C>T 
      polymorphism is related to bronchial asthma in Uighur children, and the T allele 
      may constitute a susceptibility factor in this group. Furthermore, this genetic 
      variant can result in raised IgE levels and decreased FEV1 values, suggesting 
      that both factors are associated with bronchial asthma in Uighur children.
FAU - Zhang, J H
AU  - Zhang JH
AD  - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
FAU - Zhou, G H
AU  - Zhou GH
AD  - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
FAU - Wei, T T
AU  - Wei TT
AD  - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
FAU - Chang, Z S
AU  - Chang ZS
AD  - Department of Anorectal Surgery, Shanghai Seventh People's Hospital, Shanghai, 
      China zhongshengchangcn@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160725
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Asian People/genetics
MH  - Asthma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-4/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
COIS- The authors declare no conflict of interest.
EDAT- 2016/08/16 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/08/16 06:00
PHST- 2016/08/16 06:00 [entrez]
PHST- 2016/08/16 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - gmr8363 [pii]
AID - 10.4238/gmr.15038363 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Jul 25;15(3). doi: 10.4238/gmr.15038363.