PMID- 27528060
OWN - NLM
STAT- MEDLINE
DCOM- 20190201
LR  - 20190201
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 25
IP  - 39
DP  - 2018
TI  - Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards 
      Antidiabetic Drug Development.
PG  - 5395-5431
LID - 10.2174/0929867323666160813222436 [doi]
AB  - Over the years, natural products have shown success as antidiabetics in in vitro, 
      in vivo studies and clinical trials. Because natural product-derived drugs are 
      more affordable and effective with fewer side-effects compared to conventional 
      therapies, pharmaceutical research is increasingly leaning towards the discovery 
      of new antidiabetic drugs from natural products targeting pathways or components 
      associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the 
      drug discovery process is very lengthy and costly with significant challenges. 
      Therefore, various techniques are currently being developed for the preclinical 
      research phase of drug discovery with the aim of drug development with less time 
      and efforts from natural products. In this review, we have provided an update on 
      natural products including fruits, vegetables, spices, nuts, beverages and 
      mushrooms with potential antidiabetic activities from in vivo, in vitro and 
      clinical studies. Synergistic interactions between natural products and 
      antidiabetic drugs, and potential antidiabetic active compounds from natural 
      products are also documented to pave the way for combination treatment and new 
      drug discovery, respectively. Additionally, a brief idea of the drug discovery 
      process along with the challenges that arise during drug development from natural 
      products and the methods to conquer those challenges are discussed to create a 
      more convenient future drug discovery process.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Alam, Fahmida
AU  - Alam F
AD  - Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 
      Kubang Kerian, Kelantan, Malaysia.
FAU - Islam, Md Asiful
AU  - Islam MA
AD  - Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 
      Kubang Kerian, Kelantan, Malaysia.
FAU - Kamal, Mohammad Amjad
AU  - Kamal MA
AD  - King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi 
      Arabia.
AD  - Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
AD  - Novel Global Community Educational Foundation 7 Peterlee Place, Hebersham, NSW 
      2770, Australia.
FAU - Gan, Siew Hua
AU  - Gan SH
AD  - Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 
      Kubang Kerian, Kelantan, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Biological Products)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Sulfonylurea Compounds)
RN  - 6KY687524K (glimepiride)
RN  - 9100L32L2N (Metformin)
RN  - G4PX8C4HKV (Gliclazide)
SB  - IM
MH  - Biological Products/chemistry/pharmacology/*therapeutic use
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism/pathology
MH  - Drug Discovery
MH  - Gliclazide/chemistry/pharmacology/therapeutic use
MH  - Glucose Transporter Type 4/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/chemistry/pharmacology/*therapeutic use
MH  - Metformin/chemistry/pharmacology/therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Sulfonylurea Compounds/chemistry/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - antidiabetic drugs
OT  - drug development
OT  - in vitro
OT  - in vivo
OT  - natural products
OT  - synergistic interaction.
EDAT- 2016/08/17 06:00
MHDA- 2019/02/02 06:00
CRDT- 2016/08/17 06:00
PHST- 2016/05/01 00:00 [received]
PHST- 2016/06/18 00:00 [revised]
PHST- 2016/07/08 00:00 [accepted]
PHST- 2016/08/17 06:00 [pubmed]
PHST- 2019/02/02 06:00 [medline]
PHST- 2016/08/17 06:00 [entrez]
AID - CMC-EPUB-77752 [pii]
AID - 10.2174/0929867323666160813222436 [doi]
PST - ppublish
SO  - Curr Med Chem. 2018;25(39):5395-5431. doi: 10.2174/0929867323666160813222436.