PMID- 2752916
OWN - NLM
STAT- MEDLINE
DCOM- 19890830
LR  - 20190903
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 23
IP  - 3
DP  - 1989 Jun
TI  - P-hydroxy-norephedrine as a possible mediator causing the reduction of oral 
      intake of D-amphetamine in rats.
PG  - 247-53
AB  - In rats D-amphetamine is predominantly metabolized by hydroxylation to 
      p-hydroxy-norephedrine (p-HNE); in guinea pigs, however, by deamination to 
      benzoic acid. After 2-3 days on dosages of 1 mg/kg per day and more rats begin to 
      reduce their oral intake of the stimulant whereas guinea pigs do not. In the 
      present study we examined the hypothesis that the formation of p-HNE in the CNS 
      is partially responsible for this aversion. To determine the elimination of 
      D-amphetamine and the increase in p-HNE, groups of male Wistar rats were given 
      various doses (0.5-5 mg/kg per day) of D-amphetamine in their drinking water 
      intragastrically and intravenously. D-Amphetamine in the brain was determined by 
      radioimmunoassay, p-HNE by high performance liquid chromatography followed by 
      electrochemical detection. In contrast to the concentration of D-amphetamine, the 
      p-HNE-content is independent of the route of administration; after oral treatment 
      it showed a linear increase. The results reveal that p-HNE induces the aversion 
      to the stimulant and that the ratio of D-amphetamine to its metabolite determines 
      the onset of this aversion. No p-HNE was found in the brain of guinea pigs. 
      Guinea pigs do not show any aversion to drinking D-amphetamine solutions, even in 
      high dosages.
FAU - Janicke, B
AU  - Janicke B
AD  - Department of Neuropsychopharmacology, Free University, Berlin, F.R.G.
FAU - Heil, T
AU  - Heil T
FAU - Coper, H
AU  - Coper H
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 33RU150WUN (Phenylpropanolamine)
RN  - 552-85-2 (p-Hydroxynorephedrine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Brain/metabolism
MH  - Dextroamphetamine/*administration & dosage/pharmacokinetics
MH  - Dose-Response Relationship, Drug
MH  - Guinea Pigs
MH  - Male
MH  - Phenylpropanolamine/*analogs & derivatives
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Self Administration
MH  - p-Hydroxynorephedrine/*pharmacokinetics
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 0376-8716(89)90088-4 [pii]
AID - 10.1016/0376-8716(89)90088-4 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 1989 Jun;23(3):247-53. doi: 10.1016/0376-8716(89)90088-4.