PMID- 27529221
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20240325
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 8
DP  - 2016 Aug 11
TI  - Punicalagin Mollifies Lead Acetate-Induced Oxidative Imbalance in Male 
      Reproductive System.
LID - 10.3390/ijms17081269 [doi]
LID - 1269
AB  - Punicalagin (PU) is a known antioxidant. The present study examined PU to protect 
      against lead-induced oxidative stress (OS) testicular damage in mice. Significant 
      increase in lipid peroxidation (LPO) after intraperitoneal injection of lead 
      acetate (LA) indicated enormous generation of reactive oxygen species (ROS). 
      Lead-induced OS has a direct effect on the differentiation of spermatogonial 
      cells, showing a significant decline in sperm count. Supplementation of PU 
      significantly changes values of LPO and glutathione (GSH) with a concomitant 
      increase in sperm count, a marked decrease in the abnormal sperms, and a decline 
      in the morphologically abnormal sperm population. Moreover, the histopathological 
      evaluation of testes and epididymides showed severe changes in mice treated with 
      LA. PU significantly induced nuclear factor erythroid-2 related factor 2-like 2 
      (Nrf2) expression and phase II enzymes, and data suggest that PU may inhibit OS 
      through Nrf2 activation. The fertility test proved that PU might play an 
      important role in male infertility treatment, especially in the type of 
      infertility induced by OS.
FAU - Rao, Faiza
AU  - Rao F
AD  - Institute of Immunology and CAS (Chinese Academy of Sciences) Key Laboratory of 
      Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School 
      of Life Sciences and Medical Center, University of Science and Technology of 
      China, Hefei 230027, Anhui, China. rao.faiza@yahoo.com.
AD  - Hefei National Laboratory for Physical Sciences at Microscale, Hefei 230027, 
      Anhui, China. rao.faiza@yahoo.com.
FAU - Zhai, Yiwen
AU  - Zhai Y
AD  - Institute of Immunology and CAS (Chinese Academy of Sciences) Key Laboratory of 
      Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School 
      of Life Sciences and Medical Center, University of Science and Technology of 
      China, Hefei 230027, Anhui, China. zhyiwen@mail.ustc.edu.cn.
AD  - Hefei National Laboratory for Physical Sciences at Microscale, Hefei 230027, 
      Anhui, China. zhyiwen@mail.ustc.edu.cn.
FAU - Sun, Fei
AU  - Sun F
AD  - International Peace Maternity &Child Health Hospital. School of Medicine, 
      Shanghai Jiaotong University, Shanghai 200025, China. sunfei@shsmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160811
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antioxidants)
RN  - 0 (Hydrolyzable Tannins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 65995-63-3 (punicalagin)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - RX077P88RY (lead acetate)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Glutathione/metabolism
MH  - Hydrolyzable Tannins/*pharmacology
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Mice
MH  - NF-E2-Related Factor 2/metabolism
MH  - Organometallic Compounds/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Sperm Count
MH  - Spermatozoa/drug effects
MH  - Superoxide Dismutase/metabolism
MH  - Testis/drug effects
PMC - PMC5000667
OTO - NOTNLM
OT  - fertility
OT  - lead acetate
OT  - oxidative stress
OT  - punicalagin
OT  - testicular damage
EDAT- 2016/08/17 06:00
MHDA- 2017/04/18 06:00
PMCR- 2016/08/01
CRDT- 2016/08/17 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/07/26 00:00 [revised]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/08/17 06:00 [entrez]
PHST- 2016/08/17 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - ijms17081269 [pii]
AID - ijms-17-01269 [pii]
AID - 10.3390/ijms17081269 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Aug 11;17(8):1269. doi: 10.3390/ijms17081269.