PMID- 27529810
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20181113
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 80
IP  - 6
DP  - 2016 Dec
TI  - ERP evidence of preserved early memory function in term infants with neonatal 
      encephalopathy following therapeutic hypothermia.
PG  - 800-808
LID - 10.1038/pr.2016.169 [doi]
AB  - BACKGROUND: Neonatal encephalopathy (NE) carries high risk for neurodevelopmental 
      impairments. Therapeutic hypothermia (TH) reduces this risk, particularly for 
      moderate encephalopathy (ME). Nevertheless, these infants often have subtle 
      functional deficits, including abnormal memory function. Detection of deficits at 
      the earliest possible time-point would allow for intervention during a period of 
      maximal brain plasticity. METHODS: Recognition memory function in 22 infants with 
      NE treated with TH was compared to 23 healthy controls using event-related 
      potentials (ERPs) at 2 wk of age. ERPs were recorded to mother's voice 
      alternating with a stranger's voice to assess attentional responses (P2), novelty 
      detection (slow wave), and discrimination between familiar and novel (difference 
      wave). Development was tested at 12 mo using the Bayley Scales of Infant 
      Development, Third Edition (BSID-III). RESULTS: The NE group showed similar ERP 
      components and BSID-III scores to controls. However, infants with NE showed 
      discrimination at midline leads (P = 0.01), whereas controls showed 
      discrimination in the left hemisphere (P = 0.05). Normal MRI (P = 0.05) and 
      seizure-free electroencephalogram (EEG) (P = 0.04) correlated positively with 
      outcomes. CONCLUSION: Infants with NE have preserved recognition memory function 
      after TH. The spatially different recognition memory processing after early brain 
      injury may represent compensatory changes in the brain circuitry and reflect a 
      benefit of TH.
FAU - Pfister, Katie M
AU  - Pfister KM
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
AD  - Center for Neurobehavioral Development, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Clinical and Translational Science Institute, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Miller, Neely C
AU  - Miller NC
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
AD  - Center for Neurobehavioral Development, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Hultgren, Solveig
AU  - Hultgren S
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
FAU - Boys, Chris J
AU  - Boys CJ
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
FAU - Georgieff, Michael K
AU  - Georgieff MK
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
AD  - Center for Neurobehavioral Development, University of Minnesota, Minneapolis, 
      Minnesota.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160816
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
SB  - IM
MH  - Acoustic Stimulation
MH  - Attention/physiology
MH  - Brain Diseases/physiopathology/*psychology/*therapy
MH  - Case-Control Studies
MH  - Child Development/physiology
MH  - Electroencephalography
MH  - Evoked Potentials
MH  - Female
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Memory/*physiology
EDAT- 2016/08/17 06:00
MHDA- 2017/10/24 06:00
CRDT- 2016/08/17 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2016/08/17 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2016/08/17 06:00 [entrez]
AID - pr2016169 [pii]
AID - 10.1038/pr.2016.169 [doi]
PST - ppublish
SO  - Pediatr Res. 2016 Dec;80(6):800-808. doi: 10.1038/pr.2016.169. Epub 2016 Aug 16.