PMID- 27530086
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20181202
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 22
IP  - 1
DP  - 2017 Jan
TI  - Gas exchange responses during 6-min walk test in patients with pulmonary arterial 
      hypertension.
PG  - 165-171
LID - 10.1111/resp.12868 [doi]
AB  - BACKGROUND AND OBJECTIVE: The 6-min walk test (6MWT) is the most widely utilized 
      method of assessing exercise capacity in pulmonary arterial hypertension (PAH). 
      Cardiopulmonary exercise testing has the advantage of providing additional 
      physiological information over 6MWT. The goals of our study were to describe the 
      addition of gas exchange measurements to 6MWT and to determine how these 
      parameters were related to the severity of PAH in three major subgroups of PAH 
      (idiopathic (IPAH), connective tissue disease-related (CTPAH) and congenital 
      heart disease-related (CHPAH)). METHODS: Seventy-six PAH patients (IPAH, n = 28; 
      CTPAH, n = 24; CHPAH, n = 24) completed the 6MWT with simultaneous gas exchange 
      measurements. The 6-min walk distance (6MWD), oxygen uptake ( V   O(2) ), carbon 
      dioxide production ( V   CO(2) ), oxygen saturation, minute ventilation to carbon 
      dioxide output ( V   (E) / V   CO(2) ) and end-tidal partial pressure for carbon 
      dioxide (P(ET) CO(2) ) were compared between subgroups, different functional 
      classes (FCs) and pharmacotherapy. RESULTS: Whilst no significant difference in 
      6MWT was observed, absolute V   O(2) and V   CO(2) were higher for IPAH 
      (P < 0.05). Differences were removed when V   O(2) and V   CO(2) were expressed 
      relative to body mass (i.e. mL/kg/min). CHPAH had the most significant 
      desaturation during 6MWT (CPAH: 73 +/- 15%; CTPAH: 90 +/- 8%, IPAH: 92 +/- 8%, 
      P < 0.01). There was no difference in V   (E) / V   CO(2) and P(ET) CO(2) between 
      groups; however, New York Health Association (NYHA) FC II performed better than 
      FC III subjects in 6MWT with lower V   (E) / V   CO(2) and higher end-exercise 
      P(ET) CO(2) . Similarly, individuals on more advanced pharmacotherapy (triple 
      therapy vs monotherapy) had poorer gas exchange during exercise. CONCLUSION: 
      Whilst 6MWT and gas exchange did not differentiate between PAH groups, 
      individuals with more severe disease and on more advanced pharmacotherapy had 
      poorer gas exchange during exercise.
CI  - (c) 2016 Asian Pacific Society of Respirology.
FAU - Morris, Norman R
AU  - Morris NR
AD  - School of Allied Health Sciences, Menzies Health Institute Queensland, Griffith 
      University, Gold Coast, Queensland, Australia.
AD  - Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, 
      Queensland, Australia.
FAU - Seale, Helen
AU  - Seale H
AD  - Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, 
      Queensland, Australia.
FAU - Harris, Julie
AU  - Harris J
AD  - Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, 
      Queensland, Australia.
FAU - Hall, Kathleen
AU  - Hall K
AD  - Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, 
      Queensland, Australia.
FAU - Lin, Aaron C W
AU  - Lin AC
AD  - School of Allied Health Sciences, Menzies Health Institute Queensland, Griffith 
      University, Gold Coast, Queensland, Australia.
FAU - Kermeen, Fiona
AU  - Kermeen F
AD  - Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, 
      Queensland, Australia.
LA  - eng
PT  - Journal Article
DEP - 20160816
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
MH  - Adult
MH  - Aged
MH  - Connective Tissue Diseases/*complications
MH  - Exercise Tolerance
MH  - *Familial Primary Pulmonary Hypertension/diagnosis/etiology/physiopathology
MH  - Female
MH  - Heart Defects, Congenital/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Circulation
MH  - *Pulmonary Gas Exchange
MH  - Respiratory Function Tests/methods
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Walk Test/*methods
OTO - NOTNLM
OT  - 6-min walk test
OT  - disease severity
OT  - exercise and pulmonary rehabilitation
OT  - gas exchange
OT  - pulmonary circulation
EDAT- 2016/08/18 06:00
MHDA- 2017/12/12 06:00
CRDT- 2016/08/18 06:00
PHST- 2015/12/09 00:00 [received]
PHST- 2016/05/26 00:00 [revised]
PHST- 2016/06/06 00:00 [accepted]
PHST- 2016/08/18 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2016/08/18 06:00 [entrez]
AID - 10.1111/resp.12868 [doi]
PST - ppublish
SO  - Respirology. 2017 Jan;22(1):165-171. doi: 10.1111/resp.12868. Epub 2016 Aug 16.