PMID- 27530472
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20220409
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 70
IP  - 12
DP  - 2016 Dec
TI  - Associations of dietary intakes of anthocyanins and berry fruits with risk of 
      type 2 diabetes mellitus: a systematic review and meta-analysis of prospective 
      cohort studies.
PG  - 1360-1367
LID - 10.1038/ejcn.2016.142 [doi]
AB  - To investigate the associations of dietary intakes of anthocyanins and berry 
      fruits with type 2 diabetes mellitus (T2DM) risk and to evaluate the potential 
      dose-response relationships based on prospective cohort studies. Cochrane 
      library, Embase and PubMed databases were systematically searched up to Jan 2016 
      for relevant original studies. Summary relative risks (RRs) were calculated with 
      a random effects model comparing the highest with lowest category. Dose-response 
      was estimated using restricted cubic spline regression models. Three cohort 
      studies reporting dietary anthocyanin intake with 200 894 participants and 12 611 
      T2DM incident cases, and five cohort studies reporting berry intake with 194 019 
      participants and 13 013 T2DM incident cases were investigated. Dietary 
      anthocyanin consumption was associated with a 15% reduction of T2DM risk (summary 
      RR=0.85; 95% confidence interval (CI): 0.80-0.91; I(2)=14.5%). Consumption of 
      berries was associated with an 18% reduction of T2DM risk (summary RR=0.82, 95% 
      CI: 0.76-0.89; I(2)=48.6%). Significant curvilinear associations were found 
      between dietary intake of anthocyanins (P for nonlinearity=0.006) and berries (P 
      for nonlinearity=0.028) and T2DM risk, respectively. The risk of T2DM was 
      decreased by 5%, with a 7.5 mg/day increment of dietary anthocyanin intake 
      (RR=0.95; 95% CI: 0.93-0.98; I(2)=0.00%) or with a 17 g/day increment of berry 
      intake (RR=0.95, 95% CI: 0.91-0.99; I(2)=0.00%), respectively. Higher dietary 
      intakes of anthocyanins and berry fruits are associated with a lower T2DM risk.
FAU - Guo, X
AU  - Guo X
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
FAU - Yang, B
AU  - Yang B
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
FAU - Tan, J
AU  - Tan J
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
FAU - Jiang, J
AU  - Jiang J
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
FAU - Li, D
AU  - Li D
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160817
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Anthocyanins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anthocyanins/*administration & dosage/analysis
MH  - Diabetes Mellitus, Type 2/epidemiology/etiology/*prevention & control
MH  - *Eating
MH  - Female
MH  - *Fruit
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk
EDAT- 2016/08/18 06:00
MHDA- 2018/01/06 06:00
CRDT- 2016/08/18 06:00
PHST- 2015/08/14 00:00 [received]
PHST- 2016/06/07 00:00 [revised]
PHST- 2016/07/04 00:00 [accepted]
PHST- 2016/08/18 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2016/08/18 06:00 [entrez]
AID - ejcn2016142 [pii]
AID - 10.1038/ejcn.2016.142 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2016 Dec;70(12):1360-1367. doi: 10.1038/ejcn.2016.142. Epub 2016 
      Aug 17.