PMID- 27530474
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20220129
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Print)
IS  - 0954-3007 (Linking)
VI  - 71
IP  - 1
DP  - 2017 Jan
TI  - Fruit and vegetable intake and risk of incident of type 2 diabetes: results from 
      the consortium on health and ageing network of cohorts in Europe and the United 
      States (CHANCES).
PG  - 83-91
LID - 10.1038/ejcn.2016.143 [doi]
AB  - BACKGROUND/OBJECTIVES: There is limited information to support definitive 
      recommendations concerning the role of diet in the development of type 2 Diabetes 
      mellitus (T2DM). The results of the latest meta-analyses suggest that an 
      increased consumption of green leafy vegetables may reduce the incidence of 
      diabetes, with either no association or weak associations demonstrated for total 
      fruit and vegetable intake. Few studies have, however, focused on older subjects. 
      SUBJECTS/METHODS: The relationship between T2DM and fruit and vegetable intake 
      was investigated using data from the NIH-AARP study and the EPIC Elderly study. 
      All participants below the age of 50 and/or with a history of cancer, diabetes or 
      coronary heart disease were excluded from the analysis. Multivariate logistic 
      regression analysis was used to calculate the odds ratio of T2DM comparing the 
      highest with the lowest estimated portions of fruit, vegetable, green leafy 
      vegetables and cabbage intake. RESULTS: Comparing people with the highest and 
      lowest estimated portions of fruit, vegetable or green leafy vegetable intake 
      indicated no association with the risk of T2DM. However, although the pooled OR 
      across all studies showed no effect overall, there was significant heterogeneity 
      across cohorts and independent results from the NIH-AARP study showed that fruit 
      and green leafy vegetable intake was associated with a reduced risk of T2DM OR 
      0.95 (95% CI 0.91,0.99) and OR 0.87 (95% CI 0.87,0.90) respectively. CONCLUSIONS: 
      Fruit and vegetable intake was not shown to be related to incident T2DM in older 
      subjects. Summary analysis also found no associations between green leafy 
      vegetable and cabbage intake and the onset of T2DM. Future dietary pattern 
      studies may shed light on the origin of the heterogeneity across populations.
FAU - Mamluk, L
AU  - Mamluk L
AD  - UKCRC Centre of Excellence for Public Health for Northern Ireland, Queens 
      University Belfast, Belfast, UK.
FAU - O'Doherty, M G
AU  - O'Doherty MG
AD  - UKCRC Centre of Excellence for Public Health for Northern Ireland, Queens 
      University Belfast, Belfast, UK.
FAU - Orfanos, P
AU  - Orfanos P
AD  - Department of Hygiene, University of Athens, Epidemiology and Medical Statistics, 
      Athens, Greece.
FAU - Saitakis, G
AU  - Saitakis G
AD  - Department of Hygiene, University of Athens, Epidemiology and Medical Statistics, 
      Athens, Greece.
FAU - Woodside, J V
AU  - Woodside JV
AD  - UKCRC Centre of Excellence for Public Health for Northern Ireland, Queens 
      University Belfast, Belfast, UK.
FAU - Liao, L M
AU  - Liao LM
AD  - Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, 
      National Cancer Institute, Rockville, MD, USA.
FAU - Sinha, R
AU  - Sinha R
AD  - Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, 
      National Cancer Institute, Rockville, MD, USA.
FAU - Boffetta, P
AU  - Boffetta P
AD  - The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount 
      Sinai School of Medicine, New York, NY, USA.
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Trichopoulou, A
AU  - Trichopoulou A
AD  - Department of Hygiene, University of Athens, Epidemiology and Medical Statistics, 
      Athens, Greece.
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Kee, F
AU  - Kee F
AD  - UKCRC Centre of Excellence for Public Health for Northern Ireland, Queens 
      University Belfast, Belfast, UK.
LA  - eng
GR  - G0901793/MRC_/Medical Research Council/United Kingdom
GR  - ZIA CP010196-10/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160817
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology/prevention & control
MH  - Eating/*physiology
MH  - Europe/epidemiology
MH  - Female
MH  - *Fruit
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prospective Studies
MH  - Risk Factors
MH  - United States/epidemiology
MH  - *Vegetables
PMC - PMC5658787
MID - NIHMS913502
COIS- Conflict of interest: The authors declare that they have no conflict of interest.
EDAT- 2016/08/18 06:00
MHDA- 2018/01/13 06:00
PMCR- 2017/10/27
CRDT- 2016/08/18 06:00
PHST- 2015/11/03 00:00 [received]
PHST- 2016/06/30 00:00 [revised]
PHST- 2016/07/11 00:00 [accepted]
PHST- 2016/08/18 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/08/18 06:00 [entrez]
PHST- 2017/10/27 00:00 [pmc-release]
AID - ejcn2016143 [pii]
AID - 10.1038/ejcn.2016.143 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2017 Jan;71(1):83-91. doi: 10.1038/ejcn.2016.143. Epub 2016 Aug 
      17.