PMID- 27533013
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20171126
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 45
IP  - 2
DP  - 2016 Aug 16
TI  - Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and 
      Immunogenic Dendritic Cell Maturation in Thymus and Periphery.
PG  - 305-18
LID - S1074-7613(16)30292-8 [pii]
LID - 10.1016/j.immuni.2016.07.019 [doi]
AB  - Dendritic cells (DCs) are instrumental in the initiation of T cell responses, but 
      how thymic and peripheral tolerogenic DCs differ globally from Toll-like receptor 
      (TLR)-induced immunogenic DCs remains unclear. Here, we show that thymic XCR1(+) 
      DCs undergo a high rate of maturation, accompanied by profound gene-expression 
      changes that are essential for central tolerance and also happen in germ-free 
      mice. Those changes largely overlap those occurring during tolerogenic and, more 
      unexpectedly, TLR-induced maturation of peripheral XCR1(+) DCs, arguing against 
      the commonly held view that tolerogenic DCs undergo incomplete maturation. 
      Interferon-stimulated gene (ISG) expression was among the few discriminators of 
      immunogenic and tolerogenic XCR1(+) DCs. Tolerogenic XCR1(+) thymic DCs were, 
      however, unique in expressing ISGs known to restrain virus 
      replication. Therefore, a broad functional convergence characterizes tolerogenic 
      and immunogenic XCR1(+) DC maturation in the thymus and periphery, maximizing 
      antigen presentation and signal delivery to developing and to conventional and 
      regulatory mature T cells.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Ardouin, Laurence
AU  - Ardouin L
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Luche, Herve
AU  - Luche H
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France; Centre d'Immunophenomique, Aix Marseille Universite, 
      INSERM, CNRS, 13288 Marseille, France.
FAU - Chelbi, Rabie
AU  - Chelbi R
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Carpentier, Sabrina
AU  - Carpentier S
AD  - MI-mAbs, Aix Marseille Universite, 13288 Marseille, France.
FAU - Shawket, Alaa
AU  - Shawket A
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Montanana Sanchis, Frederic
AU  - Montanana Sanchis F
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Santa Maria, Camille
AU  - Santa Maria C
AD  - Centre d'Immunophenomique, Aix Marseille Universite, INSERM, CNRS, 13288 
      Marseille, France.
FAU - Grenot, Pierre
AU  - Grenot P
AD  - Centre d'Immunophenomique, Aix Marseille Universite, INSERM, CNRS, 13288 
      Marseille, France.
FAU - Alexandre, Yannick
AU  - Alexandre Y
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Gregoire, Claude
AU  - Gregoire C
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Fries, Anissa
AU  - Fries A
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Vu Manh, Thien-Phong
AU  - Vu Manh TP
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Tamoutounour, Samira
AU  - Tamoutounour S
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Crozat, Karine
AU  - Crozat K
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Tomasello, Elena
AU  - Tomasello E
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Jorquera, Audrey
AU  - Jorquera A
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Fossum, Even
AU  - Fossum E
AD  - Institute of Immunology, University of Oslo and Oslo University Hospital 
      Rikshospitalet, 0424 Oslo, Norway.
FAU - Bogen, Bjarne
AU  - Bogen B
AD  - Institute of Immunology, University of Oslo and Oslo University Hospital 
      Rikshospitalet, 0424 Oslo, Norway.
FAU - Azukizawa, Hiroaki
AU  - Azukizawa H
AD  - Department of Dermatology, Osaka University, Osaka 565-0871, Japan.
FAU - Bajenoff, Marc
AU  - Bajenoff M
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Henri, Sandrine
AU  - Henri S
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France.
FAU - Dalod, Marc
AU  - Dalod M
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France. Electronic address: dalod@ciml.univ-mrs.fr.
FAU - Malissen, Bernard
AU  - Malissen B
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM, CNRS, 
      13288 Marseille, France; Centre d'Immunophenomique, Aix Marseille Universite, 
      INSERM, CNRS, 13288 Marseille, France. Electronic address: 
      bernardm@ciml.univ-mrs.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (XC chemokine receptor 1, mouse)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - *Central Tolerance
MH  - Dendritic Cells/*immunology
MH  - Interferon Regulatory Factors/genetics
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - *Peripheral Tolerance
MH  - Receptors, Chemokine/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Thymus Gland/*immunology
MH  - Toll-Like Receptors/immunology
MH  - Transcriptome
MH  - Virus Replication
EDAT- 2016/08/18 06:00
MHDA- 2017/09/20 06:00
CRDT- 2016/08/18 06:00
PHST- 2015/10/10 00:00 [received]
PHST- 2016/02/29 00:00 [revised]
PHST- 2016/05/25 00:00 [accepted]
PHST- 2016/08/18 06:00 [entrez]
PHST- 2016/08/18 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
AID - S1074-7613(16)30292-8 [pii]
AID - 10.1016/j.immuni.2016.07.019 [doi]
PST - ppublish
SO  - Immunity. 2016 Aug 16;45(2):305-18. doi: 10.1016/j.immuni.2016.07.019.